Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. - Wikidata - wikimedia - TriplyDB

Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.

Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.

http://www.wikidata.org/entity/Q33544118

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Heterodimerization of BAK and MCL-1 activated by detergent micelles General Sensitization of melanoma cells for TRAIL-induced apoptosis by the potassium channel inhibitor TRAM-34 depends on release of SMAC Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.The TRAIL of oncogenes to apoptosis.Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo.Nuclear and cytoplasmic p53 suppress cell invasion by inhibiting respiratory complex-I activity via Bcl-2 family proteins.Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode Killing of resistant cancer cells with low Bak by a combination of an antimesothelin immunotoxin and a TRAIL Receptor 2 agonist antibody.Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells.Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak.On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics.Bax/Bak-independent mitochondrial depolarization and reactive oxygen species induction by sorafenib overcome resistance to apoptosis in renal cell carcinoma.Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Prostate Cancer Cells after Treatment with Xanthohumol-A Natural Compound Present in Humulus lupulus L.Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers Death ligands and granulysin: mechanisms of tumor cell death induction and therapeutic opportunities.Caspase-3 feedback loop enhances Bid-induced AIF/endoG and Bak activation in Bax and p53-independent manner.ROS-dependent phosphorylation of Bax by wortmannin sensitizes melanoma cells for TRAIL-induced apoptosis.Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax Activation of mitochondrial apoptosis pathways in cutaneous squamous cell carcinoma cells by diclofenac/hyaluronic acid is related to upregulation of Bad as well as downregulation of Mcl-1 and Bcl-w.Switching from aerobic glycolysis to oxidative phosphorylation modulates the sensitivity of mantle cell lymphoma cells to TRAIL.How plausible is the use of dietary n-3 PUFA in the adjuvant therapy of cancer?Bak and Mcl-1 are essential for Temozolomide induced cell death in human glioma.KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL.Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels.Glucose--a sweet way to die: metabolic switching modulates tumor cell death.Bcl-xL/Bak interaction and regulation by miRNA let-7b in the intrinsic apoptotic pathway of stored platelets.Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.Clitocine potentiates TRAIL-mediated apoptosis in human colon cancer cells by promoting Mcl-1 degradation.Pan-class I PI3-kinase inhibitor BKM120 induces MEK1/2-dependent mitotic catastrophe in non-Hodgkin lymphoma leading to apoptosis or polyploidy determined by Bax/Bak and p53.BH3-only proteins: possible proapoptotic triggers for melanoma therapy.

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Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.

http://www.wikidata.org/entity/Q33544118

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Endogenous Bak inhibitors Mcl- ...... ce in Bax-deficient carcinoma.

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Journal of Cell Biology

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Endogenous Bak inhibitors Mcl- ...... nce in Bax-deficient carcinoma

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P2093

Anja Richter

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Annika Müer

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Antje Richter

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Bernd Dörken

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Bernhard Gillissen

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Claus Belka

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Jana Wendt

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Nina Gebhardt

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Peter T Daniel

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P2860

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX

Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma

Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway

Irradiation specifically sensitises solid tumour cell lines to TRAIL mediated apoptosis

Structural insights into the degradation of Mcl-1 induced by BH3 domains

The kiss of death: promises and failures of death receptors and ligands in cancer therapy

P304

851-862

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scholarly article

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10.1083/JCB.200912070

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P433

6

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188

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Robert Preissner

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2010-03-01T00:00:00Z

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42389412

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20308427

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2845080

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