The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. - Wikidata - wikimedia - TriplyDB

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

http://www.wikidata.org/entity/Q33559643

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Guidelines for the use and interpretation of assays for monitoring autophagy Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies Hypoxia signaling pathways: modulators of oxygen-related organelles Protein Folding and Mechanisms of Proteostasis DangER: protein ovERload. Targeting protein degradation to treat myeloma Pushing tumor cells towards a malignant phenotype: stimuli from the microenvironment, intercellular communications and alternative roads The role of autophagy in the pathogenesis of diabetic nephropathy HLA-B27 misfolding and ankylosing spondylitis Autophagy and radiosensitization in cancer Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise Autophagy and cancer cell metabolism The multifaceted roles of autophagy in tumors-implications for breast cancer.Glioblastoma, hypoxia and autophagy: a survival-prone 'ménage-à-trois'Autophagy-Dependent Secretion: Contribution to Tumor Progression Adipose tissue dysfunction and its effects on tumor metabolism Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage The tumor microenvironment and strategies to improve drug distribution PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4 The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1 Mfn2 modulates the UPR and mitochondrial function via repression of PERK Overexpression of Atg5 in mice activates autophagy and extends lifespan The unfolded protein response in immunity and inflammation Autophagy and the integrated stress response The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition.Paneth cells as a site of origin for intestinal inflammation.Protective effect of Dl-3n-butylphthalide on learning and memory impairment induced by chronic intermittent hypoxia-hypercapnia exposure Autophagy inhibition for chemosensitization and radiosensitization in cancer: do the preclinical data support this therapeutic strategy?EGFR-targeted mAb therapy modulates autophagy in head and neck squamous cell carcinoma through NLRX1-TUFM protein complex Overexpression of smooth muscle myosin heavy chain leads to activation of the unfolded protein response and autophagic turnover of thick filament-associated proteins in vascular smooth muscle cells PGRN induces impaired insulin sensitivity and defective autophagy in hepatic insulin resistance Latent factor analysis to discover pathway-associated putative segmental aneuploidies in human cancers.Decreased ATF4 expression as a mechanism of acquired resistance to long-term amino acid limitation in cancer cells Autophagy in the placenta.Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets

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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

http://www.wikidata.org/entity/Q33559643

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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Journal of Clinical Investigation

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The unfolded protein response ...... phagy genes MAP1LC3B and ATG5.

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P2093

Albert J van der Kogel

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Hilda Mujcic

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Jan Willem Voncken

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Kasper M A Rouschop

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Kim Savelkouls

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Ludwig Dubois

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Philippe Lambin

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Tom Keulers

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Twan van den Beucken

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Willy Landuyt

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P2860

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

Roles of CHOP/GADD153 in endoplasmic reticulum stress

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control.

Inhibition of macroautophagy triggers apoptosis

The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha.

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells

Autophagy: molecular machinery for self-eating

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127-141

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10.1172/JCI40027

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1

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120

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Bradly G. Wouters

Marianne Koritzinsky

Hanneke Niessen

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2009-12-14T00:00:00Z

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20038797

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2798689

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