Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.
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Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,Bisubstrate Adenylation Inhibitors of Biotin Protein Ligase from Mycobacterium tuberculosisIdentification of functional differences in metabolic networks using comparative genomics and constraint-based modelsComprehensive spectroscopic, steady state, and transient kinetic studies of a representative siderophore-associated flavin monooxygenaseBisubstrate Inhibitors of Biotin Protein Ligase in Mycobacterium tuberculosis Resistant to Cyclonucleoside Formation.High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv.Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis.Analyses of MbtB, MbtE, and MbtF suggest revisions to the mycobactin biosynthesis pathway in Mycobacterium tuberculosisStructural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.General platform for systematic quantitative evaluation of small-molecule permeability in bacteria.Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.The tuberculosis drug discovery and development pipeline and emerging drug targets.Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategyDeciphering the Structural Requirements of Nucleoside Bisubstrate Analogues for Inhibition of MbtA in Mycobacterium tuberculosis: A FB-QSAR Study and Combinatorial Library Generation for Identifying Potential Hits.Development of a selective activity-based probe for adenylating enzymes: profiling MbtA Involved in siderophore biosynthesis from Mycobacterium tuberculosis.Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosisReaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.Investigation and conformational analysis of fluorinated nucleoside antibiotics targeting siderophore biosynthesis.Preparation of bifunctional isocyanate hydroxamate linkers: Synthesis of carbamate and urea tethered polyhydroxamic acid chelators.Synthesis and pharmacological evaluation of nucleoside prodrugs designed to target siderophore biosynthesis in Mycobacterium tuberculosis.Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?2-Aryl-8-aza-3-deazaadenosine analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: Nucleoside antibiotics that block siderophore biosynthesis in Mycobacterium tuberculosis.Iron trafficking as an antimicrobial targetAryl acid adenylating enzymes involved in siderophore biosynthesis: fluorescence polarization assay, ligand specificity, and discovery of non-nucleoside inhibitors via high-throughput screening.Synthesis of chromone, quinolone, and benzoxazinone sulfonamide nucleosides as conformationally constrained inhibitors of adenylating enzymes required for siderophore biosynthesis.Engineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display.Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosisIs drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin "Trojan Horse" antibiotics and synthetic desferridanoxamine-antibiotic conjugatesMultisubstrate adduct inhibitors: drug design and biological tools.Novel agents to inhibit microbial virulence and pathogenicity.Recent advances in the research of heterocyclic compounds as antitubercular agents.Biosynthesis of mycobacterial lipids by polyketide synthases and beyond.Tuberculosis drug discovery and emerging targets.Nucleoside analogs and tuberculosis: new weapons against an old enemy.Anti-virulence Strategies to Target Bacterial Infections.Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli.Quantitative three dimensional structure linear interaction energy model of 5'-O-[N-(salicyl)sulfamoyl]adenosine and the aryl acid adenylating enzyme MbtA.Efficient Pd-catalyzed coupling of tautomerizable heterocycles with terminal alkynes via C-OH bond activation using PyBrOP.
P2860
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P2860
Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.
description
2008 nî lūn-bûn
@nan
2008 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Inhibition of siderophore bios ...... nucleobase domain of 5'-O-[N-
@nl
Inhibition of siderophore bios ...... -(salicyl)sulfamoyl]adenosine.
@ast
Inhibition of siderophore bios ...... -(salicyl)sulfamoyl]adenosine.
@en
type
label
Inhibition of siderophore bios ...... nucleobase domain of 5'-O-[N-
@nl
Inhibition of siderophore bios ...... -(salicyl)sulfamoyl]adenosine.
@ast
Inhibition of siderophore bios ...... -(salicyl)sulfamoyl]adenosine.
@en
prefLabel
Inhibition of siderophore bios ...... nucleobase domain of 5'-O-[N-
@nl
Inhibition of siderophore bios ...... -(salicyl)sulfamoyl]adenosine.
@ast
Inhibition of siderophore bios ...... -(salicyl)sulfamoyl]adenosine.
@en
P2093
P2860
P356
P1476
Inhibition of siderophore bios ...... -(salicyl)sulfamoyl]adenosine.
@en
P2093
Courtney C Aldrich
Daniel J Wilson
Eric M Bennett
Helena I Boshoff
Jagadeshwar Vannada
Liqiang Chen
Nicholas P Labello
Ravindranadh V Somu
P2860
P304
P356
10.1021/JM800567V
P407
P577
2008-08-09T00:00:00Z