Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity.
about
Mitochondrial DNA replication and disease: insights from DNA polymerase γ mutationsFunctional roles of the N- and C-terminal regions of the human mitochondrial single-stranded DNA-binding proteinPolg2 is essential for mammalian embryogenesis and is required for mtDNA maintenanceAnalysis of Translesion DNA Synthesis by the Mitochondrial DNA Polymerase γA mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial diseaseMitochondrial genome maintenance in health and disease.A single mutation in human mitochondrial DNA polymerase Pol gammaA affects both polymerization and proofreading activities of only the holoenzyme.Role of histidine 932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease.Biochemical analysis of human POLG2 variants associated with mitochondrial disease.Evolution of the metazoan mitochondrial replicase.Clustering of Alpers disease mutations and catalytic defects in biochemical variants reveal new features of molecular mechanism of the human mitochondrial replicase, Pol γ.Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicasePOLG2 disease variants: analyses reveal a dominant negative heterodimer, altered mitochondrial localization and impaired respiratory capacity.Mitochondrial Single-stranded DNA-binding Proteins Stimulate the Activity of DNA Polymerase γ by Organization of the Template DNA.Mapping 136 pathogenic mutations into functional modules in human DNA polymerase γ establishes predictive genotype-phenotype correlations for the complete spectrum of POLG syndromes.Biolayer Interferometry: A Novel Method to Elucidate Protein-Protein and Protein-DNA Interactions in the Mitochondrial DNA ReplisomeTranslesion synthesis past acrolein-derived DNA adducts by human mitochondrial DNA polymerase γClinical and molecular features of POLG-related mitochondrial disease.Animal Mitochondrial DNA Replication.Exonuclease of human DNA polymerase gamma disengages its strand displacement function.Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progressionA transient kinetic approach to investigate nucleoside inhibitors of mitochondrial DNA polymerase gamma.Structural insight on processivity, human disease and antiviral drug toxicity.Mitochondrial DNA maintenance: an appraisal.Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome
P2860
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P2860
Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
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2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
Each monomer of the dimeric ac ...... le in conferring processivity.
@ast
Each monomer of the dimeric ac ...... le in conferring processivity.
@en
Each monomer of the dimeric ac ...... le in conferring processivity.
@nl
type
label
Each monomer of the dimeric ac ...... le in conferring processivity.
@ast
Each monomer of the dimeric ac ...... le in conferring processivity.
@en
Each monomer of the dimeric ac ...... le in conferring processivity.
@nl
prefLabel
Each monomer of the dimeric ac ...... le in conferring processivity.
@ast
Each monomer of the dimeric ac ...... le in conferring processivity.
@en
Each monomer of the dimeric ac ...... le in conferring processivity.
@nl
P2093
P2860
P921
P356
P1476
Each monomer of the dimeric ac ...... le in conferring processivity.
@en
P2093
Borries Demeler
Ian J Molineux
Kenneth A Johnson
Y Whitney Yin
Young-Sam Lee
P2860
P304
P356
10.1074/JBC.M109.062752
P407
P577
2009-10-26T00:00:00Z