Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy
about
Gene regulation, alternative splicing, and posttranslational modification of troponin subunits in cardiac development and adaptation: a focused reviewLong term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathyThe heart-specific NH2-terminal extension regulates the molecular conformation and function of cardiac troponin IA novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysisTNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.Diastolic dysfunction and thin filament dysregulation resulting from excitation-contraction uncoupling in a mouse model of restrictive cardiomyopathy.Ca(2+)-regulatory function of the inhibitory peptide region of cardiac troponin I is aided by the C-terminus of cardiac troponin T: Effects of familial hypertrophic cardiomyopathy mutations cTnI R145G and cTnT R278C, alone and in combination, on filDeficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycinDiastolic dysfunction and cardiac troponin I decrease in aging hearts.Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins.Strong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach.Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: a clinical, genetic, and functional approachNH2-terminal truncations of cardiac troponin I and cardiac troponin T produce distinct effects on contractility and calcium homeostasis in adult cardiomyocytesApplication of echocardiography on transgenic mice with cardiomyopathies.Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity.Cardiac arrhythmia and heart failure: From bench to bedsideInsights into restrictive cardiomyopathy from clinical and animal studies.In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility GeneDecreasing tropomyosin phosphorylation rescues tropomyosin-induced familial hypertrophic cardiomyopathyMyofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration.Muscle dysfunction in hypertrophic cardiomyopathy: what is needed to move to translation?Experimental models of inherited cardiomyopathy and its therapeutics.Early sensitization of myofilaments to Ca2+ prevents genetically linked dilated cardiomyopathy in mice.Restrictive Cardiomyopathy Caused by Troponin Mutations: Application of Disease Animal Models in Translational StudiesEffect of hypertrophic cardiomyopathy-linked troponin C mutations on the response of reconstituted thin filaments to calcium upon troponin I phosphorylation.Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin I (K206I)Dose-dependent diastolic dysfunction and early death in a mouse model with cardiac troponin mutations.Green tea extract catechin improves internal cardiac muscle relaxation in RCM mice.Protective effects of taurine against oxidative stress in the heart of MsrA knockout mice.Role of Whole-exome Sequencing in Phenotype Classification and Clinical Treatment of Pediatric Restrictive Cardiomyopathy.The continuing evolution of cardiac troponin I biomarker analysis: from protein to proteoform.Echocardiographic evaluation of diastolic function in mouse models of heart disease.
P2860
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P2860
Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy
description
2010 nî lūn-bûn
@nan
2010 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy
@ast
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy
@en
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy.
@nl
type
label
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy
@ast
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy
@en
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy.
@nl
prefLabel
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy
@ast
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy
@en
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy.
@nl
P2093
P2860
P1476
Correcting diastolic dysfuncti ...... of restrictive cardiomyopathy
@en
P2093
Changlong Nan
Han-Zhong Feng
James D Potter
Jingsheng Liang
Pierre-Yves Jean Charles
Xupei Huang
Yingcai Wang
P2860
P304
P356
10.1016/J.YJMCC.2010.04.017
P577
2010-05-15T00:00:00Z