20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling
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Vascular actions of 20-HETE20-HETE and blood pressure regulation: clinical implicationsCytochrome P450-derived eicosanoids and vascular dysfunction in coronary artery disease patientsRenal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient MiceJujuboside B Reduces Vascular Tension by Increasing Ca2+ Influx and Activating Endothelial Nitric Oxide SynthaseBioactive lipid mediators in polycystic kidney diseaseVascular characterization of mice with endothelial expression of cytochrome P450 4F2.Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKKβ/IκB-α/NF-κB pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock.The role of 20-HETE in androgen-mediated hypertension.Role of the CYP4A/20-HETE pathway in vascular dysfunction of the Dahl salt-sensitive rat.CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent20-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis.20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (Gq) to Affect Vascular Function and Trigger Hypertension.Androgen-dependent hypertension is mediated by 20-hydroxy-5,8,11,14-eicosatetraenoic acid-induced vascular dysfunction: role of inhibitor of kappaB Kinase.Elevated level of pro-inflammatory eicosanoids and EPC dysfunction in diabetic patients with cardiac ischemia20-Hydroxyeicosatetraenoic acid contributes to the inhibition of K+ channel activity and vasoconstrictor response to angiotensin II in rat renal microvesselsIsoproterenol induces vascular oxidative stress and endothelial dysfunction via a Giα-coupled β2-adrenoceptor signaling pathway20-Hydroxyeicosatetraenoic acid impairs endothelial insulin signaling by inducing phosphorylation of the insulin receptor substrate-1 at Ser616.Urinary CYP eicosanoid excretion correlates with glomerular filtration in African-Americans with chronic kidney disease.Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertensionCerebral Perfusion Enhancing Interventions: A New Strategy for the Prevention of Alzheimer Dementia.pNaKtide inhibits Na/K-ATPase reactive oxygen species amplification and attenuates adipogenesis.20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter BindingTreatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock20-HETE induces remodeling of renal resistance arteries independent of blood pressure elevation in hypertensionMolecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology.20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertensionNovel signalling mechanisms and targets in renal ischaemia and reperfusion injury.Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy.Modulation of cardiac cytochrome P450 in patients with heart failure.Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging.Effect of Cytochrome P450 Metabolites of Arachidonic Acid in Nephrology.Contribution of PPARα/β/γ, AP-1, importin-α3, and RXRα to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against hypotension, tachycardia, and inflammation in a rat model of septic shock.Role of vascular reactive oxygen species in regulating cytochrome P450-4A enzyme expression in Dahl salt-sensitive rats.Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction.Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in human monocytes.Introgression of Brown Norway CYP4A genes on to the Dahl salt-sensitive background restores vascular function in SS-5(BN) consomic rats.Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.
P2860
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P2860
20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
20-hydroxy-5,8,11,14-eicosatet ...... tric-oxide synthase uncoupling
@ast
20-hydroxy-5,8,11,14-eicosatet ...... tric-oxide synthase uncoupling
@en
20-hydroxy-5,8,11,14-eicosatet ...... ric-oxide synthase uncoupling.
@nl
type
label
20-hydroxy-5,8,11,14-eicosatet ...... tric-oxide synthase uncoupling
@ast
20-hydroxy-5,8,11,14-eicosatet ...... tric-oxide synthase uncoupling
@en
20-hydroxy-5,8,11,14-eicosatet ...... ric-oxide synthase uncoupling.
@nl
prefLabel
20-hydroxy-5,8,11,14-eicosatet ...... tric-oxide synthase uncoupling
@ast
20-hydroxy-5,8,11,14-eicosatet ...... tric-oxide synthase uncoupling
@en
20-hydroxy-5,8,11,14-eicosatet ...... ric-oxide synthase uncoupling.
@nl
P2093
P2860
P356
P1476
20-hydroxy-5,8,11,14-eicosatet ...... tric-oxide synthase uncoupling
@en
P2093
Cheng-Chia Wu
Dubasi Narsimhaswamy
Frank Zhang
Jennifer Cheng
Katherine H Gotlinger
Michal Laniado Schwartzman
P2860
P356
10.1124/JPET.109.159863
P407
P577
2009-10-19T00:00:00Z