p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence
about
The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancerAlterations of microRNAs contribute to colon carcinogenesisUncovering the role of p53 splice variants in human malignancy: a clinical perspectiveMolecular Mechanisms of p53 Deregulation in Cancer: An Overview in Multiple MyelomaDifferential Impacts of Alternative Splicing Networks on ApoptosisModulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response.Role of senescence and mitotic catastrophe in cancer therapy.MiRNA profile associated with replicative senescence, extended cell culture, and ectopic telomerase expression in human foreskin fibroblasts.The isoforms of the p53 proteinClinical outcomes and correlates of TP53 mutations and cancer.P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferationTracing the protectors path from the germ line to the genome.Immortalization of MEF is characterized by the deregulation of specific miRNAs with potential tumor suppressor activityp53 Isoforms: An Intracellular Microprocessor?The essence of senescence.The relative mRNA expression of p53 isoforms in breast cancer is associated with clinical features and outcome.Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel diseasep53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damageThe ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.p53 governs telomere regulation feedback too, via TRF2.Effects of Δ40p53, an isoform of p53 lacking the N-terminus, on transactivation capacity of the tumor suppressor protein p53.p53 protein isoforms: key regulators in the front line of pathogen infections?Cancer-associated fibroblasts and their putative role in potentiating the initiation and development of epithelial ovarian cancer.p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients.MicroRegulators come of age in senescence.Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice.Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancerRAS transformation requires CUX1-dependent repair of oxidative DNA damage.Functional role of cellular senescence in biliary injuryp53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damagep53 Family: Role of Protein Isoforms in Human Cancer.Biological functions of p53 isoforms through evolution: lessons from animal and cellular models.Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a ∆133p53α mimic.Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progressionAlternative RNA splicing and cancermiR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesisTranslational approaches targeting the p53 pathway for anti-cancer therapy.TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome.Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide.p53 basic C terminus regulates p53 functions through DNA binding modulation of subset of target genes
P2860
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P2860
p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence
description
2009 nî lūn-bûn
@nan
2009 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
p53 isoforms Delta133p53 and p ...... eplicative cellular senescence
@ast
p53 isoforms Delta133p53 and p ...... eplicative cellular senescence
@en
p53 isoforms Delta133p53 and p ...... plicative cellular senescence.
@nl
type
label
p53 isoforms Delta133p53 and p ...... eplicative cellular senescence
@ast
p53 isoforms Delta133p53 and p ...... eplicative cellular senescence
@en
p53 isoforms Delta133p53 and p ...... plicative cellular senescence.
@nl
prefLabel
p53 isoforms Delta133p53 and p ...... eplicative cellular senescence
@ast
p53 isoforms Delta133p53 and p ...... eplicative cellular senescence
@en
p53 isoforms Delta133p53 and p ...... plicative cellular senescence.
@nl
P2093
P2860
P356
P1433
P1476
p53 isoforms Delta133p53 and p ...... eplicative cellular senescence
@en
P2093
Aaron J Schetter
Abdul M Mondal
Borivoj Vojtesek
Curtis C Harris
Elise D Bowman
Ewy A Mathe
Giang H Nguyen
Izumi Horikawa
Jane J Sohn
P2860
P2888
P304
P356
10.1038/NCB1928
P577
2009-08-23T00:00:00Z
P5875
P6179
1019118231