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Huntington's disease: silencing a brutal killer.

Huntington's disease: silencing a brutal killer.

http://www.wikidata.org/entity/Q33586461

about

A natural antisense transcript at the Huntington's disease repeat locus regulates HTT expression Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin.Allele-selective inhibition of huntingtin expression by switching to an miRNA-like RNAi mechanism.State-of-the-art human gene therapy: part II. Gene therapy strategies and clinical applications.Huntington's disease: progress toward effective disease-modifying treatments and a cure Prospects for neuroprotective therapies in prodromal Huntington's disease.Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease.Targeting individual calpain isoforms for neuroprotection.Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework.

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P2860

Huntington's disease: silencing a brutal killer.

http://www.wikidata.org/entity/Q33586461

description

2009 nî lūn-bûn

@nan

2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Huntington's disease: silencing a brutal killer.

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Huntington's disease: silencing a brutal killer.

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Huntington's disease: silencing a brutal killer.

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type

label

Huntington's disease: silencing a brutal killer.

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Huntington's disease: silencing a brutal killer.

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Huntington's disease: silencing a brutal killer.

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prefLabel

Huntington's disease: silencing a brutal killer.

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Huntington's disease: silencing a brutal killer.

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Huntington's disease: silencing a brutal killer.

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J.EXPNEUROL.2009.09.017

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Experimental Neurology

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Huntington's disease: silencing a brutal killer.

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Edith L Pfister

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P2860

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup

A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1

Strategies for silencing human disease using RNA interference

Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

Designing siRNA that distinguish between genes that differ by a single nucleotide

Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease.

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226-229

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scholarly article

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10.1016/J.EXPNEUROL.2009.09.017

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Phillip D. Zamore

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26852971

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