Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity. - Wikidata - wikimedia - TriplyDB

Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.

Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.

http://www.wikidata.org/entity/Q33588771

about

Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes Design, synthesis, and biological evaluation of stable colchicine binding site tubulin inhibitors as potential anticancer agents.Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1 A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia.Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland.25-OH Vitamin D and Interleukin-8: Emerging Biomarkers in Cutaneous Melanoma Development and Progression Chemical Synthesis and Biological Activities of 20S,24S/R-Dihydroxyvitamin D3 Epimers and Their 1α-Hydroxyl Derivatives.On the role of skin in the regulation of local and systemic steroidogenic activities.Total synthesis of biologically active 20S-hydroxyvitamin D3.Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4.Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D3 Analogs.Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation.On the role of classical and novel forms of vitamin D in melanoma progression and management.Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer.Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes.Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management.Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORα and RORγ.

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P2860

Novel vitamin D analogs as potential therapeutics: metabolism, toxicity profiling, and antiproliferative activity.

http://www.wikidata.org/entity/Q33588771

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Novel vitamin D analogs as pot ...... nd antiproliferative activity.

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Novel vitamin D analogs as pot ...... nd antiproliferative activity.

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Novel vitamin D analogs as pot ...... nd antiproliferative activity.

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Novel vitamin D analogs as pot ...... nd antiproliferative activity.

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Novel vitamin D analogs as pot ...... nd antiproliferative activity.

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Anticancer Research

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Novel vitamin D analogs as pot ...... nd antiproliferative activity.

@en

P2093

Andrzej T Slominski

http://www.w3.org/2001/XMLSchema#string

Arnold Postlethwaite

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Dianne Kovacic

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Duane D Miller

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Edith K Y Tang

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Elaine W Tieu

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Jianjun Chen

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Jin Wang

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Robert C Tuckey

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Tae-Kang Kim

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P2860

Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes.

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells.

Expression of vitamin D receptor decreases during progression of pigmented skin lesions.

Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity.

Vitamin D receptor as a drug discovery target.

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