Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane
about
TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytesD-chiro-inositol glycans in insulin signaling and insulin resistanceHyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factorNOD1 activators link innate immunity to insulin resistanceSelective insulin resistance in adipocytesGLUT4 exocytosis.Amplification and demultiplexing in insulin-regulated Akt protein kinase pathway in adipocytes.The association of ClipR-59 protein with AS160 modulates AS160 protein phosphorylation and adipocyte Glut4 protein membrane translocationThe Rab GTPase-activating protein TBC1D4/AS160 contains an atypical phosphotyrosine-binding domain that interacts with plasma membrane phospholipids to facilitate GLUT4 trafficking in adipocytes.Optogenetic activation reveals distinct roles of PIP3 and Akt in adipocyte insulin action.Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle.Impairments in site-specific AS160 phosphorylation and effects of exercise training.Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle.Mapping insulin/GLUT4 circuitry.Rac-1 superactivation triggers insulin-independent glucose transporter 4 (GLUT4) translocation that bypasses signaling defects exerted by c-Jun N-terminal kinase (JNK)- and ceramide-induced insulin resistance.Akt inhibitors reduce glucose uptake independently of their effects on Akt.Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia.Late Endosomal Recycling of Open MHC-I Conformers.Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle.
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P2860
Cluster analysis of insulin action in adipocytes reveals a key role for Akt at the plasma membrane
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Cluster analysis of insulin ac ...... for Akt at the plasma membrane
@ast
Cluster analysis of insulin ac ...... for Akt at the plasma membrane
@en
type
label
Cluster analysis of insulin ac ...... for Akt at the plasma membrane
@ast
Cluster analysis of insulin ac ...... for Akt at the plasma membrane
@en
prefLabel
Cluster analysis of insulin ac ...... for Akt at the plasma membrane
@ast
Cluster analysis of insulin ac ...... for Akt at the plasma membrane
@en
P2093
P2860
P50
P356
P1476
Cluster analysis of insulin ac ...... for Akt at the plasma membrane
@en
P2093
Adelle C F Coster
Jacqueline Stöckli
P2860
P304
P356
10.1074/JBC.M109.060236
P407
P577
2009-11-06T00:00:00Z