Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia - Wikidata - wikimedia - TriplyDB

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

http://www.wikidata.org/entity/Q33594629

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Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Histone methyltransferases: novel targets for tumor and developmental defects Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine Childhood acute lymphoblastic leukemia: Integrating genomics into therapy Frequent somatic mutations in epigenetic regulators in newly diagnosed chronic myeloid leukemia.Childhood B-acute lymphoblastic leukemia: a genetic update.Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.Pediatric cancer epigenome and the influence of folate High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.Loss of histone H3 lysine 36 trimethylation is associated with an increased risk of renal cell carcinoma-specific death Mutations in epigenetic regulators are involved in acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation.Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas.Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations.Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia.Genetic drivers of vulnerability and resistance in relapsed acute lymphoblastic leukemia.Eye on the B-ALL: B-cell receptor repertoires reveal persistence of numerous B-lymphoblastic leukemia subclones from diagnosis to relapse.The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia.Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.Novel methods and approaches to acute lymphoblastic leukemia drug discovery.Epigenetics in T-cell acute lymphoblastic leukemia.Genomics in acute lymphoblastic leukaemia: insights and treatment implications.Towards an understanding of the biology and targeted treatment of paediatric relapsed acute lymphoblastic leukaemia.Identification of SETD2-NF1 fusion gene in a pediatric spindle cell tumor with the chromosomal translocation t(3;17)(p21;q12).SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis.Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation Dual Chromatin and Cytoskeletal Remodeling by SETD2.Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma.H3K36 methyltransferases as cancer drug targets: rationale and perspectives for inhibitor development Genomic characterization of paediatric acute lymphoblastic leukaemia: an opportunity for precision medicine therapeutics.Shaping the cellular landscape with Set2/SETD2 methylation.Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia.Expanding the SRI domain family: a common scaffold for binding the phosphorylated C-terminal domain of RNA polymerase II.Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas.ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.Mutational profiling of acute lymphoblastic leukemia with testicular relapse.Genomic complexity and dynamics of clonal evolution in childhood acute myeloid leukemia studied with whole-exome sequencing.Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP.Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.

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P2860

Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia

http://www.wikidata.org/entity/Q33594629

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Mutations in epigenetic regula ...... acute lymphoblastic leukaemia

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Mutations in epigenetic regula ...... acute lymphoblastic leukaemia

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type

label

Mutations in epigenetic regula ...... acute lymphoblastic leukaemia

@ast

Mutations in epigenetic regula ...... acute lymphoblastic leukaemia

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prefLabel

Mutations in epigenetic regula ...... acute lymphoblastic leukaemia

@ast

Mutations in epigenetic regula ...... acute lymphoblastic leukaemia

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Nature Communications

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Mutations in epigenetic regula ...... acute lymphoblastic leukaemia

@en

P2093

Amit U Sinha

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Benjamin L Ebert

http://www.w3.org/2001/XMLSchema#string

Donna S Neuberg

http://www.w3.org/2001/XMLSchema#string

Kathleen M McLean

http://www.w3.org/2001/XMLSchema#string

Kristen Stevenson

http://www.w3.org/2001/XMLSchema#string

Lars B Bullinger

http://www.w3.org/2001/XMLSchema#string

Lewis B Silverman

http://www.w3.org/2001/XMLSchema#string

Luca Lo Nigro

http://www.w3.org/2001/XMLSchema#string

Marian H Harris

http://www.w3.org/2001/XMLSchema#string

Peter V Grauman

http://www.w3.org/2001/XMLSchema#string

P2860

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL.

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

CREBBP mutations in relapsed acute lymphoblastic leukaemia.

Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.

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10.1038/NCOMMS4469

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5

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2014-03-24T00:00:00Z

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1000269131

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