Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. - Wikidata - wikimedia - TriplyDB

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q34670390

about

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression Histone methyltransferases: novel targets for tumor and developmental defects Progress in epigenetic histone modification analysis by mass spectrometry for clinical investigations The interplay of histone modifications - writers that read Mutation of chromatin modifiers; an emerging hallmark of germinal center B-cell lymphomas Proteomics-based discovery of biomarkers for paediatric acute lymphoblastic leukaemia: challenges and opportunities Redefining ALL classification: toward detecting high-risk ALL and implementing precision medicine Structural variation discovery in the cancer genome using next generation sequencing: computational solutions and perspectives Gain-of-function mutation of chromatin regulators as a tumorigenic mechanism and an opportunity for therapeutic intervention Quantitative proteomic analysis of histone modifications Mutations in epigenetic regulators including SETD2 are gained during relapse in paediatric acute lymphoblastic leukaemia In vitro clinical trials: the future of cell-based profiling.Childhood B-acute lymphoblastic leukemia: a genetic update.Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation.Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation Stable-isotope-labeled histone peptide library for histone post-translational modification and variant quantification by mass spectrometry The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.Chemical profiling of the genome with anti-cancer drugs defines target specificities.Pediatric T-cell lymphoblastic leukemia evolves into relapse by clonal selection, acquisition of mutations and promoter hypomethylation.Developmental control of polycomb subunit composition by GATA factors mediates a switch to non-canonical functions.Rise and fall of subclones from diagnosis to relapse in pediatric B-acute lymphoblastic leukaemia.Mutational spectrum of adult T-ALL Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.Large-Scale Targeted Proteomics Using Internal Standard Triggered-Parallel Reaction Monitoring (IS-PRM).Pathology Tissue-quantitative Mass Spectrometry Analysis to Profile Histone Post-translational Modification Patterns in Patient Samples.Reduced-representation Phosphosignatures Measured by Quantitative Targeted MS Capture Cellular States and Enable Large-scale Comparison of Drug-induced Phenotypes Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL).Targeting EZH2 and PRC2 dependence as novel anticancer therapy.A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes.Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin.Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs.NSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation.Epigenetics of hematopoiesis and hematological malignancies.Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer Development of a sequential workflow based on LC-PRM for the verification of endometrial cancer protein biomarkers in uterine aspirate samples.Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach.The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia.

P2860

Q26766149-72B856DB-10A9-4429-ABB0-8E83D1D1B2EA Q26775027-E9207587-505F-48CB-9FE8-3983B6A0042E Q26781745-B4553136-7C74-4F7F-B5B2-0E0C39214BBF Q26782196-43066EC2-BC22-448C-8B36-E155DAA2E452 Q26782506-9B0A3C7C-99EF-48D1-9AD0-B751345897D1 Q26861489-4C326C52-58B6-4E41-B873-F079A86A6CAD Q26864460-F306D5F9-122F-4FA8-9F1B-9675EF64FFA9 Q26991436-7095D731-7A2B-4E7C-AAE9-DAB59AF1F8BC Q27024233-C3B437AE-DC0C-41FE-8970-14A4E5BF4CF9 Q30375585-F2251099-433C-4BA7-9C48-39C0B18704D7 Q33594629-7B01E753-8A07-4F76-851A-419D14A0FBA0 Q33676812-40B01509-66F7-4B47-964D-B11BDEA7A91E Q33777616-4CEAD349-F20C-4A1C-97C9-57299627FA6E Q33798890-AB53184D-5702-40F3-A06D-2815C5F2DE7A Q33842762-1A8CEF7E-7E5B-4ABB-8A1F-898F0E913A6E Q34133622-53D656A7-DE50-4F54-B06F-3279E1E65AB2 Q34157702-ABE98943-2005-4E9C-9221-7A2899FC7D19 Q34414087-985BA279-ACF9-4BEF-9E31-F4AC114CEDF8 Q34475915-761A6961-3C70-40EC-B2B7-E1BE43671141 Q34490429-CAAD755F-3BA5-48A8-8FC0-B6D4A0A95EEE Q35007905-E61C10A0-DC62-44CC-AC04-A600C0E75AA6 Q35227439-A6C35988-877A-4C0A-83B2-B915962788EA Q35550090-E54C3895-18CC-4685-A3B2-59FFF6793B0D Q35692081-8CA11369-F73E-4D03-B05D-DA0E2E7608FE Q35692132-B8EC1FE9-9E87-464A-B139-9999ECAD387F Q35805423-0E1C4602-38F1-4D69-A80C-DEADA835E6BE Q35935148-48AEE3A3-3298-4AA7-A889-0F027DA800AC Q36040373-9BA22342-FED5-4780-B351-65E1D34F52BD Q36243352-44C056B4-FB80-4421-9B35-AFBE046EAD70 Q36445523-B8A2ADA8-8B3D-4CEE-A378-116DE6966AC0 Q36450242-5DE7646A-1094-4AFE-8EB7-69F3C4E4247C Q36745131-7E2ED482-B56B-4D89-AB75-C23E663698E4 Q36884617-E269117A-CF1A-4231-93FA-F689CEEA935A Q36956610-71A878E3-36B8-4832-9D4A-9E2828455C2A Q37240015-42F5D341-7DEB-4162-A9CA-CAB57E63987C Q37343797-6AD6B606-4201-4571-8F33-4F459A88C86E Q37592666-C82E2836-7271-4E48-9FDC-280CA2E37B05 Q37619708-CA7EA9A5-F8DE-46B9-ACD5-34960C00BC23 Q37623655-F3810D3C-030D-417B-8C4D-6236E53BD3C3 Q37629537-262A8E33-2AD9-49E0-8D0B-E08645048D52

P2860

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia.

http://www.wikidata.org/entity/Q34670390

description

2013 nî lūn-bûn

@nan

2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@ast

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@en

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@nl

type

label

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@ast

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@en

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@nl

prefLabel

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@ast

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@en

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@nl

P1433

Q34670390-F1E57760-EB07-4B71-8A6F-EBF090A4EE34

P1476

Q34670390-8E437946-C88A-420D-88C9-F86E2E2CEFAE

P2093

Q34670390-010145BD-ED05-4760-B751-135207D6CFC9

Q34670390-1C09A31A-C7F5-4F73-9633-D9EC7E0EDF32

Q34670390-2DC35CF5-BA7A-421A-ABC9-E3B53B91262C

Q34670390-44359233-76AD-409C-9ABF-D9AA6BBA1A54

Q34670390-4508C81F-5DCF-43EE-BEB4-450042B1C795

Q34670390-46D5D2EF-344D-4C01-9823-19AB7EBF251B

Q34670390-497A516A-448C-49AD-A8A3-313C3426EA13

Q34670390-4B2B938B-4398-45BE-8FF1-2CB44023359D

Q34670390-4B63C8DA-EA04-478C-9D89-82905A49B0A7

Q34670390-4E9B7E71-CCDC-4479-8F6D-9C6AB76750A7

P2860

Q34670390-0B815A16-2FCF-4C3A-83DE-57639B24F7B6

Q34670390-192399D3-781B-4E7A-B816-2DD6629CD59F

Q34670390-204BC978-4AC0-4A2E-9B83-E3A28F3695EE

Q34670390-27877DB9-1A2B-46CD-9DF9-81972A02D3A2

Q34670390-2B762C55-F6BB-4AA8-B702-7BE903224F3A

Q34670390-39C1BAFA-1F86-46D2-BA09-C361A5BDE9BC

Q34670390-3A444B20-3F29-4853-9FE6-21747C312785

Q34670390-4315832D-3AD3-4E23-ACF7-80C13AA34245

Q34670390-43723425-980D-4530-89DE-418C57C0AEA6

Q34670390-48A38405-F35A-4823-8575-A481D2045946

P2888

Q34670390-55566740-5BA3-4CA9-A8D9-D7BB837C2970

P304

Q34670390-F4B2793B-D247-4C9D-B46B-E516D19AE6CD

P31

Q34670390-1801F051-7679-4C2A-9B7B-B7E27AEEFF50

P356

Q34670390-CAF26554-0D95-433B-AE0C-D62782E6A638

P407

Q34670390-C05493FC-966F-4DBC-87C1-AD2BC1B34AD7

P433

Q34670390-0B8A3712-884E-49BD-847C-3EBE3443C933

P478

Q34670390-AE9EA5AD-AB14-44C9-9431-01A886B9B092

P50

Q34670390-1AA173CA-BD1C-49EB-9A52-467C2EF586B9

Q34670390-9807CB53-DC9A-46FD-B0CA-56D9441BB967

Q34670390-C687191D-AAF8-49D3-BA0C-ED9502A39811

Q34670390-E3F9088D-831C-40EB-B396-F528A59764FB

P577

Q34670390-2A096921-2E91-462E-89CA-B42E8A04A53D

P5875

Q34670390-67950035-12F2-40A2-A1DD-E4DEC731A363

P698

Q34670390-F25CD6CF-89B3-45CE-A335-47A94DA1C350

P921

Q34670390-CABDA624-E2D4-403F-860F-6AFAA1766A50

P932

Q34670390-B9F54B95-A190-40F9-91E3-392DB472429E

P356

P1433

Nature Genetics

P1476

Global chromatin profiling rev ...... acute lymphoblastic leukemia.

@en

P2093

E Robert McDonald

http://www.w3.org/2001/XMLSchema#string

Feng Yan

http://www.w3.org/2001/XMLSchema#string

Frank Stegmeier

http://www.w3.org/2001/XMLSchema#string

Giordano Caponigro

http://www.w3.org/2001/XMLSchema#string

Gregory V Kryukov

http://www.w3.org/2001/XMLSchema#string

Ho Man Chan

http://www.w3.org/2001/XMLSchema#string

Hyo-eun C Bhang

http://www.w3.org/2001/XMLSchema#string

Jacob D Jaffe

http://www.w3.org/2001/XMLSchema#string

James R Downing

http://www.w3.org/2001/XMLSchema#string

Jing Ma

http://www.w3.org/2001/XMLSchema#string

P2860

The structure of NSD1 reveals an autoregulatory mechanism underlying histone H3K36 methylation

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

The SWISS-MODEL Repository and associated resources

Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

P2888

P304

1386-1391

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NG.2777

http://www.w3.org/2001/XMLSchema#string

P407

P433

11

http://www.w3.org/2001/XMLSchema#string

P478

45

http://www.w3.org/2001/XMLSchema#string

P50

Charles G. Mullighan

Jordi Barretina

Levi A Garraway

P577

2013-09-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

257204593

http://www.w3.org/2001/XMLSchema#string

P698

24076604

http://www.w3.org/2001/XMLSchema#string

P921

P932

4262138

http://www.w3.org/2001/XMLSchema#string