Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma. - Wikidata - wikimedia - TriplyDB

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

http://www.wikidata.org/entity/Q33601156

about

EZH2 in normal hematopoiesis and hematological malignancies The epigenetic basis of diffuse large B-cell lymphoma Super-enhancers: Asset management in immune cell genomes Chromatin signatures of cancer Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review BET inhibitors in the treatment of hematologic malignancies: current insights and future prospects Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis The mechanisms behind the therapeutic activity of BET bromodomain inhibition Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability Functions of BET proteins in erythroid gene expression Targeting BET bromodomains for cancer treatment dbSUPER: a database of super-enhancers in mouse and human genome DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation Identification of a new gene regulatory circuit involving B cell receptor activated signaling using a combined analysis of experimental, clinical and global gene expression data BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells The "histone mimicry" by pathogens.Role of MYC in B Cell Lymphomagenesis.Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression.Putative enhancer sites in the bovine genome are enriched with variants affecting complex traits.The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter.Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors Identification and characterization of essential genes in the human genome.BRD4 is a histone acetyltransferase that evicts nucleosomes from chromatin.Genetic alterations of the cohesin complex genes in myeloid malignancies.BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD.Therapeutic strategies to inhibit MYC Targeting transcription regulation in cancer with a covalent CDK7 inhibitor CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor Enhancer sequence variants and transcription-factor deregulation synergize to construct pathogenic regulatory circuits in B-cell lymphoma.Resolving the daratumumab interference with blood compatibility testing.Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers.Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape.Functional, chemical genomic, and super-enhancer screening identify sensitivity to cyclin D1/CDK4 pathway inhibition in Ewing sarcoma.Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis.CDK7-dependent transcriptional addiction in triple-negative breast cancer.SEA: a super-enhancer archive.

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Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

http://www.wikidata.org/entity/Q33601156

description

2013 nî lūn-bûn

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2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年学术文章

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2013年學術文章

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name

Discovery and characterization ...... diffuse large B cell lymphoma.

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Discovery and characterization ...... diffuse large B cell lymphoma.

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type

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Discovery and characterization ...... diffuse large B cell lymphoma.

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Discovery and characterization ...... diffuse large B cell lymphoma.

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Discovery and characterization ...... diffuse large B cell lymphoma.

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Discovery and characterization ...... diffuse large B cell lymphoma.

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J.CCR.2013.11.003

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Discovery and characterization ...... diffuse large B cell lymphoma

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Bjoern Chapuy

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Charles Y Lin

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Elaine Reichert

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Heather H Sun

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James E Bradner

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John G Doench

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Jun Qi

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Kelly T Yeda

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Margaret A Shipp

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Margaretha G M Roemer

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P2860

Selective inhibition of BET bromodomains

Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells

Brd4 recruits P-TEFb to chromosomes at late mitosis to promote G1 gene expression and cell cycle progression

Histone recognition and large-scale structural analysis of the human bromodomain family

The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B

Conserved P-TEFb-interacting domain of BRD4 inhibits HIV transcription

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777-790

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