Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs.

Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs.

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http://www.wikidata.org/entity/Q33604018

Q33604018

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An oral versus intranasal prime/boost regimen using attenuated human rotavirus or VP2 and VP6 virus-like particles with immunostimulating complexes influences protection and antibody-secreting cell responses to rotavirus in a neonatal gnotobiotic pi Protective immunity and antibody-secreting cell responses elicited by combined oral attenuated Wa human rotavirus and intranasal Wa 2/6-VLPs with mutant Escherichia coli heat-labile toxin in gnotobiotic pigs.Rotavirus 2/6 virus-like particles administered intranasally in mice, with or without the mucosal adjuvants cholera toxin and Escherichia coli heat-labile toxin, induce a Th1/Th2-like immune response.Protection against aerosolized Yersinia pestis challenge following homologous and heterologous prime-boost with recombinant plague antigens.Cytokine responses in gnotobiotic pigs after infection with virulent or attenuated human rotavirus.Chimaeric virus-like particles derived from consensus genome sequences of human rotavirus strains co-circulating in Africa.Development of a Bacillus subtilis-based rotavirus vaccine Immune responses elicited against rotavirus middle layer protein VP6 inhibit viral replication in vitro and in vivo.High titers of circulating maternal antibodies suppress effector and memory B-cell responses induced by an attenuated rotavirus priming and rotavirus-like particle-immunostimulating complex boosting vaccine regimen Mice develop effective but delayed protective immune responses when immunized as neonates either intranasally with nonliving VP6/LT(R192G) or orally with live rhesus rotavirus vaccine candidates Mutants of the Escherichia coli heat-labile enterotoxin as safe and strong adjuvants for intranasal delivery of vaccines.Magnitude of serum and intestinal antibody responses induced by sequential replicating and nonreplicating rotavirus vaccines in gnotobiotic pigs and correlation with protection Porcine noroviruses related to human noroviruses.Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana Qualitative and quantitative characteristics of rotavirus-specific CD8 T cells vary depending on the route of infection.Why does the world need another rotavirus vaccine?Virus-specific intestinal IFN-gamma producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs.Rotavirus vaccines: how they work or don't work.Human rotavirus virus-like particle vaccines evaluated in a neonatal gnotobiotic pig model of human rotavirus disease.Correlates of protection against human rotavirus disease and the factors influencing protection in low-income settings.Development of a human rotavirus induced diarrhea model in Chinese mini-pigs.Systemic and intestinal antibody responses to NSP4 enterotoxin of Wa human rotavirus in a gnotobiotic pig model of human rotavirus disease.Rotavirus virus-like particles as surrogates in environmental persistence and inactivation studies.Immunogenicity and virus-like particle formation of rotavirus capsid proteins produced in transgenic plants.Rotavirus virus-like particles (RV-VLPs) vaccines: An update.Antibody responses to human rotavirus (HRV) in gnotobiotic pigs following a new prime/boost vaccine strategy using oral attenuated HRV priming and intranasal VP2/6 rotavirus-like particle (VLP) boosting with ISCOM.Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus.

P2860

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P2860

Intranasal administration of 2/6-rotavirus-like particles with mutant Escherichia coli heat-labile toxin (LT-R192G) induces antibody-secreting cell responses but not protective immunity in gnotobiotic pigs.

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2000 nî lūn-bûn

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2000年の論文

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