c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis. - Wikidata - wikimedia - TriplyDB

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.

http://www.wikidata.org/entity/Q33604849

about

A functional SUMO-interacting motif in the transactivation domain of c-Myb regulates its myeloid transforming ability c-Myb, Menin, GATA-3, and MLL form a dynamic transcription complex that plays a pivotal role in human T helper type 2 cell development Transcription factor-mediated reprogramming toward hematopoietic stem cells Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression Disordered epigenetic regulation in MLL-related leukemia.The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.High expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemia Single molecule analysis of c-myb alternative splicing reveals novel classifiers for precursor B-ALL.Prepaying the entropic cost for allosteric regulation in KIX Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.Molecular recognition by the KIX domain and its role in gene regulation.Menin immunoreactivity in secretory granules of human pancreatic islet cells Mapping of MN1 sequences necessary for myeloid transformation.Tumor suppressor menin represses paired box gene 2 expression via Wilms tumor suppressor protein-polycomb group complex Two decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program.An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance.Targeting cell cycle regulators in hematologic malignancies.Menin represses tumorigenesis via repressing cell proliferation.The histone acetyltransferase TIP60 interacts with c-Myb and inactivates its transcriptional activity in human leukemia.c-Myb Binding Sites in Haematopoietic Chromatin Landscapes BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis.Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 and Hoxa10 Estrogen receptor-α recruits P-TEFb to overcome transcriptional pausing in intron 1 of the MYB gene Cell cycle control in acute myeloid leukemia.Transposable Elements in Human Cancer: Causes and Consequences of Deregulation Interplay between menin and K-Ras in regulating lung adenocarcinoma.The MLL partial tandem duplication in adults aged 60 years and older with de novo cytogenetically normal acute myeloid leukemia PRISM offers a comprehensive genomic approach to transcription factor function prediction Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis.Menin represses malignant phenotypes of melanoma through regulating multiple pathways.Rapid Recall Ability of Memory T cells is Encoded in their Epigenome.The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis.Menin as a hub controlling mixed lineage leukemia.Role and potential for therapeutic targeting of MYB in leukemia.Menin: a scaffold protein that controls gene expression and cell signaling.

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P2860

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.

http://www.wikidata.org/entity/Q33604849

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

c-Myb binds MLL through menin ...... MLL-associated leukemogenesis.

@ast

c-Myb binds MLL through menin ...... MLL-associated leukemogenesis.

@en

type

label

c-Myb binds MLL through menin ...... MLL-associated leukemogenesis.

@ast

c-Myb binds MLL through menin ...... MLL-associated leukemogenesis.

@en

prefLabel

c-Myb binds MLL through menin ...... MLL-associated leukemogenesis.

@ast

c-Myb binds MLL through menin ...... MLL-associated leukemogenesis.

@en

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P1433

Journal of Clinical Investigation

P1476

c-Myb binds MLL through menin ...... MLL-associated leukemogenesis.

@en

P2093

Alan M Gewirtz

http://www.w3.org/2001/XMLSchema#string

Anna Kalota

http://www.w3.org/2001/XMLSchema#string

Huiwu Zhao

http://www.w3.org/2001/XMLSchema#string

Shenghao Jin

http://www.w3.org/2001/XMLSchema#string

Yan Yi

http://www.w3.org/2001/XMLSchema#string

Yuji Nakata

http://www.w3.org/2001/XMLSchema#string

P2860

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF

Menin associates with FANCD2, a protein involved in repair of DNA damage

Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

P304

593-606

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scholarly article

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10.1172/JCI38030

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P433

2

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120

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2010-01-19T00:00:00Z

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41111878

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20093773

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P932

2810070

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