Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
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Antibodies inside of a cell can change its outside: Can intrabodies provide a new therapeutic paradigm?Engineering humoral immunity as prophylaxis or therapyIntravenous immunoglobulin and Alzheimer's disease: what now?Combinatorial approaches for the identification of brain drug delivery targets.Interleukin-1β mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease.Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein.Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-α suppressive therapeutic strategies in the brain.The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5.DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease.Biochemical and morphological characterization of the AβPP/PS/tau triple transgenic mouse model and its relevance to sporadic Alzheimer's disease.Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's diseaseArginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation.Muscle-directed anti-Aβ single-chain antibody delivery via AAV1 reduces cerebral Aβ load in an Alzheimer's disease mouse model.Anti-Amyloid-β Single-Chain Antibody Brain Delivery Via AAV Reduces Amyloid Load But May Increase Cerebral Hemorrhages in an Alzheimer's Disease Mouse ModelSustained IL-1β expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells.Gene therapy for misfolding protein diseases of the central nervous system.Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease.Therapeutic potential of vaccines for Alzheimer's disease.Genetic therapy for the nervous system.Gene-based antibody strategies for prion diseases.Single-chain fragment variable passive immunotherapies for neurodegenerative diseases.Gene-based vaccines and immunotherapeutic strategies against neurodegenerative diseases: Potential utility and limitations.Gene therapy for neurological disorders.State of play and clinical prospects of antibody gene transfer.Recombinant Antibody Fragments for Neurodegenerative Diseases.Potential importance of B cells in aging and aging-associated neurodegenerative diseases.Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies.Use of self-complementary adeno-associated virus serotype 2 as a tracer for labeling axons: implications for axon regenerationHealing genes in the nervous system.Targeting Beta-Amyloid at the CSF: A New Therapeutic Strategy in Alzheimer's Disease.In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) FragmentsTargeted Intracellular Delivery of Antibodies: The State of the Art
P2860
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P2860
Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Abeta-directed single-chain an ...... y in Alzheimer's disease mice.
@ast
Abeta-directed single-chain an ...... y in Alzheimer's disease mice.
@en
type
label
Abeta-directed single-chain an ...... y in Alzheimer's disease mice.
@ast
Abeta-directed single-chain an ...... y in Alzheimer's disease mice.
@en
prefLabel
Abeta-directed single-chain an ...... y in Alzheimer's disease mice.
@ast
Abeta-directed single-chain an ...... y in Alzheimer's disease mice.
@en
P2093
P2860
P921
P356
P1433
P1476
Abeta-directed single-chain an ...... y in Alzheimer's disease mice.
@en
P2093
Deborah A Ryan
Howard J Federoff
Mark A Sullivan
Michael A Mastrangelo
Wade C Narrow
William J Bowers
P2860
P304
P356
10.1038/MT.2010.111
P577
2010-06-15T00:00:00Z