Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.
about
Designing a HER2/neu promoter to drive alpha1,3galactosyltransferase expression for targeted anti-alphaGal antibody-mediated tumor cell killing.E1A activates transcription of p73 and Noxa to induce apoptosisOverexpression of ErbB2 in cancer and ErbB2-targeting strategies.Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity.Adenovirus E1A N-terminal amino acid sequence requirements for repression of transcription in vitro and in vivo correlate with those required for E1A interference with TBP-TATA complex formation.Head and neck cancer: gene therapy approaches. Part II: genes delivered.Heregulin negatively regulates transcription of ErbB2/3 receptors via an AKT-mediated pathwayInhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene.Etoposide enhances antitumor efficacy of MDR1-driven oncolytic adenovirus through autoupregulation of the MDR1 promoter activity.FER-1, an enhancer of the ferritin H gene and a target of E1A-mediated transcriptional repression.The adenovirus E1A repression domain disrupts the interaction between the TATA binding protein and the TATA box in a manner reversible by TFIIB.Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2Identification and characterization of a novel enhancer for the rat neu promoter.Negative autoregulation of the neu gene is mediated by a novel enhancer.Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogeneMechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma.Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation.ErbB2 is required for ductal morphogenesis of the mammary gland.Transcriptional repression by human adenovirus E1A N terminus/conserved domain 1 polypeptides in vivo and in vitro in the absence of protein synthesis.E1a promotes c-Myc-dependent replicative stress: implications in glioblastoma radiosensitization.Expression of the Adenovirus Early Gene 1A Transcription-Repression Domain Alone Downregulates HER2 and Results in the Death of Human Breast Cancer Cells Upregulated for the HER2 Proto-Oncogene.Repression of RNA polymerase III transcription by adenovirus E1A.Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.An adenovirus E1A transcriptional repressor domain functions as an activator when tethered to a promoterE1A-responsive elements for repression of rat fibronectin gene transcription.Regulation of Her2/neu promoter activity by the ETS transcription factor, ER81.Adenovirus E1A down-regulates the EGF receptor via repression of its promoter.Characterization of a repressor element and a juxtaposed tissue-restricted activator element located on the distal neu gene promoter.Inhibition of tumorigenicity in lung adenocarcinoma cells by c-erbB-2 antisense expression.Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells.Regulation of the ERBB-2 promoter by RBPJkappa and NOTCH.Modulation of PI3K/Akt pathway by E1a mediates sensitivity to cisplatin.The Epstein-Barr virus nuclear antigen-1 may act as a transforming suppressor of the HER2/neu oncogene.Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis.Adenovirus-E1A gene therapy enhances the in vivo sensitivity of Ewing's sarcoma to VP-16.The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene.Tumor-specific activation of hTERT-derived promoters by tumor suppressive E1A-mutants involves recruitment of p300/CBP/HAT and suppression of HDAC-1 and defines a combined tumor targeting and suppression system.The N-terminal domain of SV40 large T antigen represses the HER2/neu-mediated transformation and metastatic potential in breast cancers.The paradox of E2F1: oncogene and tumor suppressor gene.
P2860
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P2860
Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products.
description
1990 nî lūn-bûn
@nan
1990 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Transcriptional repression of ...... denovirus 5 E1A gene products.
@ast
Transcriptional repression of ...... denovirus 5 E1A gene products.
@en
type
label
Transcriptional repression of ...... denovirus 5 E1A gene products.
@ast
Transcriptional repression of ...... denovirus 5 E1A gene products.
@en
prefLabel
Transcriptional repression of ...... denovirus 5 E1A gene products.
@ast
Transcriptional repression of ...... denovirus 5 E1A gene products.
@en
P2093
P2860
P356
P1476
Transcriptional repression of ...... denovirus 5 E1A gene products.
@en
P2093
P2860
P304
P356
10.1073/PNAS.87.12.4499
P407
P577
1990-06-01T00:00:00Z