Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene
about
A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasisOverexpression of ErbB2 in cancer and ErbB2-targeting strategies.Downregulation of microRNA miR-520h by E1A contributes to anticancer activity.Suppression of E1A-mediated transformation by the p50E4F transcription factorAxl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity.Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulationHead and neck cancer: gene therapy approaches. Part II: genes delivered.PML suppresses oncogenic transformation of NIH/3T3 cells by activated neu.Negative autoregulation of the neu gene is mediated by a novel enhancer.Antioncogenic effect of adenovirus E1A in human tumor cells.Expression of the Adenovirus Early Gene 1A Transcription-Repression Domain Alone Downregulates HER2 and Results in the Death of Human Breast Cancer Cells Upregulated for the HER2 Proto-Oncogene.Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1.Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.Inhibition of breast and ovarian tumor growth through multiple signaling pathways by using retrovirus-mediated small interfering RNA against Her-2/neu gene expression.Adenovirus E1A down-regulates the EGF receptor via repression of its promoter.Evidence for a function of CtBP in epithelial gene regulation and anoikis.Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells.Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis.Adenovirus-E1A gene therapy enhances the in vivo sensitivity of Ewing's sarcoma to VP-16.A multicenter phase II study of tgDCC-E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma.The N-terminal common domain of simian virus 40 large T and small t antigens acts as a transformation suppressor of the HER-2/neu oncogene.E1A: tumor suppressor or oncogene? Preclinical and clinical investigations of E1A gene therapy.Overexpression of the c-erbB-2/neu-encoded p185 protein in primary lung cancer.
P2860
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P2860
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene
description
1991 nî lūn-bûn
@nan
1991年の論文
@ja
1991年論文
@yue
1991年論文
@zh-hant
1991年論文
@zh-hk
1991年論文
@zh-mo
1991年論文
@zh-tw
1991年论文
@wuu
1991年论文
@zh
1991年论文
@zh-cn
name
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene
@en
type
label
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene
@en
prefLabel
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene
@en
P2093
P2860
P356
P1476
Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene
@en
P2093
P2860
P304
P356
10.1128/MCB.11.3.1745
P407
P577
1991-03-01T00:00:00Z