Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis
about
Conditionally reprogrammed normal and transformed mouse mammary epithelial cells display a progenitor-cell-like phenotypeA NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1Form and function: how estrogen and progesterone regulate the mammary epithelial hierarchySLUG: Critical regulator of epithelial cell identity in breast development and cancerCyclin D as a therapeutic target in cancerTip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expressionPhenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Claudin 1 in breast tumorigenesis: revelation of a possible novel "claudin high" subset of breast cancers.Integrin αvβ3 drives slug activation and stemness in the pregnant and neoplastic mammary gland.Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis.Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancerCyclin D1 activity regulates autophagy and senescence in the mammary epithelium.New roles of cyclin D1.DACH1 inhibits cyclin D1 expression, cellular proliferation and tumor growth of renal cancer cells.Kinase-independent role of cyclin D1 in chromosomal instability and mammary tumorigenesisThe tumour suppressor C/EBPδ inhibits FBXW7 expression and promotes mammary tumour metastasis.Targeting breast cancer stem cells.Murine mammary epithelial stem cells: discovery, function, and current status.Single unpurified breast tumor-initiating cells from multiple mouse models efficiently elicit tumors in immune-competent hosts.The dynamics of murine mammary stem/progenitor cells.Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell linesEpithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression.Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2.Cancer stem-like cells enriched in Panc-1 spheres possess increased migration ability and resistance to gemcitabine.Mammary cells with active Wnt signaling resist ErbB2-induced tumorigenesisA p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosisKeratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer.From milk to malignancy: the role of mammary stem cells in development, pregnancy and breast cancer.NF-κB, stem cells and breast cancer: the links get stronger.Cyclin D3 compensates for the loss of cyclin D1 during ErbB2-induced mammary tumor initiation and progression.MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells.Luminal-B breast cancer and novel therapeutic targets.A new role of SNAI2 in postlactational involution of the mammary gland links it to luminal breast cancer development.Prolactin promotes mammary pathogenesis independently from cyclin D1.CD151 represses mammary gland development by maintaining the niches of progenitor cells.Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasisA Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors.Overexpression of Id1 in transgenic mice promotes mammary basal stem cell activity and breast tumorigenesisNotch-induced mammary tumorigenesis does not involve the lobule-limited epithelial progenitorFunctional characterization of stem cell activity in the mouse mammary gland
P2860
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P2860
Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Cyclin D1 kinase activity is r ...... ts of MMTV-ErbB2 tumorigenesis
@ast
Cyclin D1 kinase activity is r ...... ts of MMTV-ErbB2 tumorigenesis
@en
type
label
Cyclin D1 kinase activity is r ...... ts of MMTV-ErbB2 tumorigenesis
@ast
Cyclin D1 kinase activity is r ...... ts of MMTV-ErbB2 tumorigenesis
@en
prefLabel
Cyclin D1 kinase activity is r ...... ts of MMTV-ErbB2 tumorigenesis
@ast
Cyclin D1 kinase activity is r ...... ts of MMTV-ErbB2 tumorigenesis
@en
P2093
P2860
P1433
P1476
Cyclin D1 kinase activity is r ...... ts of MMTV-ErbB2 tumorigenesis
@en
P2093
Charlotte Kuperwasser
Ina Klebba
Miaofen G Hu
Nelson E Brown
Philip W Hinds
Rinath Jeselsohn
P2860
P356
10.1016/J.CCR.2009.11.024
P577
2010-01-01T00:00:00Z