Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.
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Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsThe role of tau in neurodegenerative diseases and its potential as a therapeutic targetLysosome and calcium dysregulation in Alzheimer's disease: partners in crimeInvolvement of calpains in adult neurogenesis: implications for stroke.Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type miceCalpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.Roles of tau protein in health and disease.The contributions of myelin and axonal caliber to transverse relaxation time in shiverer and neurofilament-deficient mouse models.The myosin Va head domain binds to the neurofilament-L rod and modulates endoplasmic reticulum (ER) content and distribution within axonsSpecific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L miceGalanin fiber hyperinnervation preserves neuroprotective gene expression in cholinergic basal forebrain neurons in Alzheimer's disease.Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.Calpain and PARP activation during photoreceptor cell death in P23H and S334ter rhodopsin mutant ratsImplicating calpain in tau-mediated toxicity in vivo.Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction.Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer diseaseRemarkable reduction of MAP2 in the brains of scrapie-infected rodents and human prion disease possibly correlated with the increase of calpain.Two distinct types of dying back axonal degeneration in vitro.Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures.Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.Our "energy-Ca(2+) signaling deficits" hypothesis and its explanatory potential for key features of Alzheimer's disease.Calpain cleavage and inactivation of the sodium calcium exchanger-3 occur downstream of Aβ in Alzheimer's disease.Neuroprotective strategies against calpain-mediated neurodegeneration.Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathiesHook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generationCalpain dysregulation in Alzheimer's diseaseDissociation of Axonal Neurofilament Content from Its Transport RateAutophagy and neuronal cell death in neurological disordersCalpastatin overexpression protects axonal transport in an in vivo model of traumatic axonal injury.Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.Calpastatin inhibits motor neuron death and increases survival of hSOD1(G93A) mice.Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse.β Cell-specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity.Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis.Structure-function relationships in calpains.Hypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of Alzheimer's disease.Calpastatin upregulation in Mycoplasma hyorhinis-infected cells is promoted by the mycoplasma lipoproteins via the NF-κB pathway.Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulationNH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease.Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury.
P2860
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P2860
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: neuroprotection by CAST overexpression.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Marked calpastatin (CAST) depl ...... ection by CAST overexpression.
@ast
Marked calpastatin (CAST) depl ...... ection by CAST overexpression.
@en
type
label
Marked calpastatin (CAST) depl ...... ection by CAST overexpression.
@ast
Marked calpastatin (CAST) depl ...... ection by CAST overexpression.
@en
prefLabel
Marked calpastatin (CAST) depl ...... ection by CAST overexpression.
@ast
Marked calpastatin (CAST) depl ...... ection by CAST overexpression.
@en
P2093
P2860
P921
P1476
Marked calpastatin (CAST) depl ...... ection by CAST overexpression.
@en
P2093
Anne M Cataldo
Corrinne M Peterhoff
Dun-Sheng Yang
Jabbar Campbell
Mala V Rao
Panaiyur S Mohan
Peter A Paskevich
Philip H Stavrides
Ralph A Nixon
Stephen D Schmidt
P2860
P304
12241-12254
P356
10.1523/JNEUROSCI.4119-08.2008
P407
P577
2008-11-01T00:00:00Z