Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.
about
The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseasesINS-gene mutations: from genetics and beta cell biology to clinical diseaseThe delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiologyJagn1 Is Induced in Response to ER Stress and Regulates Proinsulin BiosynthesisBiosynthesis and secretion of mouse cysteine-rich with EGF-like domains 2A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in ApoE knockout mice by attenuating inflammatory responses.IRE1 inhibition perturbs the unfolded protein response in a pancreatic β-cell line expressing mutant proinsulin, but does not sensitize the cells to apoptosis.Characterization of hibernating ribosomes in mammalian cells.Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells.PDI reductase acts on Akita mutant proinsulin to initiate retrotranslocation along the Hrd1/Sel1L-p97 axis.Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.Genetic complexity in a Drosophila model of diabetes-associated misfolded human proinsulin.Protein disulfide isomerase A6 controls the decay of IRE1α signaling via disulfide-dependent associationRole of the unfolded protein response in β cell compensation and failure during diabetes.Insulin gene mutations and diabetesp24 family proteins: key players in the regulation of trafficking along the secretory pathway.mTOR inhibitors activate PERK signaling and favor viability of gastrointestinal neuroendocrine cell lines.Endoplasmic reticulum stress is activated in acute pancreatitis.Increased circulating concentrations of mesencephalic astrocyte-derived neurotrophic factor in children with type 1 diabetes.Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts.Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases.PERK leads a hub dictating pancreatic β cell homoeostasis.Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.Pancreatic β-cell protection from inflammatory stress by the endoplasmic reticulum proteins thrombospondin 1 and mesencephalic astrocyte-derived neutrotrophic factor (MANF).Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat.GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice.TSG-6 secreted by human adipose tissue-derived mesenchymal stem cells ameliorates severe acute pancreatitis via ER stress downregulation in mice
P2860
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P2860
Endoplasmic reticulum stress response in an INS-1 pancreatic beta-cell line with inducible expression of a folding-deficient proinsulin.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Endoplasmic reticulum stress r ...... folding-deficient proinsulin.
@ast
Endoplasmic reticulum stress r ...... folding-deficient proinsulin.
@en
type
label
Endoplasmic reticulum stress r ...... folding-deficient proinsulin.
@ast
Endoplasmic reticulum stress r ...... folding-deficient proinsulin.
@en
prefLabel
Endoplasmic reticulum stress r ...... folding-deficient proinsulin.
@ast
Endoplasmic reticulum stress r ...... folding-deficient proinsulin.
@en
P2093
P2860
P356
P1433
P1476
Endoplasmic reticulum stress r ...... folding-deficient proinsulin.
@en
P2093
Allen Volchuk
Liling Zhang
Madura Siva
Taila Hartley
Tracy Teodoro
P2860
P2888
P356
10.1186/1471-2121-11-59
P577
2010-07-26T00:00:00Z
P5875
P6179
1008872874