Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy. - Wikidata - wikimedia - TriplyDB

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

http://www.wikidata.org/entity/Q33648539

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The effect of age on thymic function Deletion of FoxN1 in the thymic medullary epithelium reduces peripheral T cell responses to infection and mimics changes of aging Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis FOXN1 in thymus organogenesis and development Thymic epithelial cell development and differentiation: cellular and molecular regulation Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence Morphogenesis and maintenance of the 3D thymic medulla and prevention of nude skin phenotype require FoxN1 in pre- and post-natal K14 epithelium Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution A Fine-Tune Role of Mir-125a-5p on Foxn1 During Age-Associated Changes in the Thymus.Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineages.Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage.The Antigenic Determinant That Defines Thymic Nurse Cells Is Expressed by Thymic Epithelial Progenitor Cells.Foxn1 regulates key target genes essential for T cell development in postnatal thymic epithelial cells Biological significance of FoxN1 gain-of-function mutations during T and B lymphopoiesis in juvenile mice.Wnt-4 protects thymic epithelial cells against dexamethasone-induced senescence.Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells Thymic involution perturbs negative selection leading to autoreactive T cells that induce chronic inflammation.Expression Analyses Revealed Thymic Stromal Co-Transporter/Slc46A2 Is in Stem Cell Populations and Is a Putative Tumor Suppressor.mTORC1 in Thymic Epithelial Cells Is Critical for Thymopoiesis, T-Cell Generation, and Temporal Control of γδT17 Development and TCRγ/δ Recombination Characterization of the Promoter Regions of Two Sheep Keratin-Associated Protein Genes for Hair Cortex-Specific Expression.Age-Related Disruption of Steady-State Thymic Medulla Provokes Autoimmune Phenotype via Perturbing Negative Selection.Thymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma.Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish.Role of the p63-FoxN1 regulatory axis in thymic epithelial cell homeostasis during aging.Thymic epithelial cell development and its dysfunction in human diseases.From murine to human nude/SCID: the thymus, T-cell development and the missing link.FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program.FOXN1 in organ development and human diseases.Developing stratified epithelia: lessons from the epidermis and thymus.Development and developmental potential of cortical thymic epithelial cells.Immune senescence: significance of the stromal microenvironment.Soluble antigens from the neurotropic pathogen Angiostrongylus cantonensis directly induce thymus atrophy in a mouse model.CRISPR/Cas9-Mediated Deletion of Foxn1 in NOD/SCID/IL2rg-/- Mice Results in Severe Immunodeficiency.Thymic involution beyond T-cell insufficiency.It's not all equal: a multiphasic theory of thymic involution.MicroRNAs Regulate Thymic Epithelium in Age-Related Thymic Involution via Down- or Upregulation of Transcription Factors.Capacity of tTreg generation is not impaired in the atrophied thymus.Thymic epithelial β-catenin is required for adult thymic homeostasis and function.Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration.

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P2860

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

http://www.wikidata.org/entity/Q33648539

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Postnatal tissue-specific disr ...... triggers acute thymic atrophy.

@ast

Postnatal tissue-specific disr ...... triggers acute thymic atrophy.

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type

label

Postnatal tissue-specific disr ...... triggers acute thymic atrophy.

@ast

Postnatal tissue-specific disr ...... triggers acute thymic atrophy.

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prefLabel

Postnatal tissue-specific disr ...... triggers acute thymic atrophy.

@ast

Postnatal tissue-specific disr ...... triggers acute thymic atrophy.

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Postnatal tissue-specific disr ...... triggers acute thymic atrophy.

@en

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Dong-Ming Su

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Jian Fu

http://www.w3.org/2001/XMLSchema#string

Jianfei Guo

http://www.w3.org/2001/XMLSchema#string

Liguang Sun

http://www.w3.org/2001/XMLSchema#string

Lili Cheng

http://www.w3.org/2001/XMLSchema#string

Peter F Barnes

http://www.w3.org/2001/XMLSchema#string

Robert G Oshima

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Takashi Amagai

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P2860

New member of the winged-helix protein family disrupted in mouse and rat nude mutations

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

The whn transcription factor encoded by the nude locus contains an evolutionarily conserved and functionally indispensable activation domain

Foxn1 is required to maintain the postnatal thymic microenvironment in a dosage-sensitive manner

Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

Analysis of thymic stromal cell populations using flow cytometry.

Genetic mechanisms in Apc-mediated mammary tumorigenesis

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