Expression and functional characteristics of calpain 3 isoforms generated through tissue-specific transcriptional and posttranscriptional events
about
A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-κB pathway in skeletal muscleProteins associated with the exon junction complex also control the alternative splicing of apoptotic regulatorsNovel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesionsMultiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscleMicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle developmentCrystal structure of calpain-3 penta-EF-hand (PEF) domain - a homodimerized PEF family member with calcium bound at the fifth EF-handSkeletal muscle-specific calpain is an intracellular Na+-dependent proteaseDisruption of the murine calpain small subunit gene, Capn4: calpain is essential for embryonic development but not for cell growth and divisionDown-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblastsMdm muscular dystrophy: interactions with calpain 3 and a novel functional role for titin's N2A domain.Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function.Inhibition of papilloma progression by antisense oligonucleotides targeted to HPV11 E6/E7 RNA.Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain.An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene.A New Insight into the Role of Calpains in Post-mortem Meat Tenderization in Domestic Animals: A review.Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation.Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms.Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.Muscle giants: molecular scaffolds in sarcomerogenesis.Regulation of the M-cadherin-beta-catenin complex by calpain 3 during terminal stages of myogenic differentiationLoss of calpain-3 autocatalytic activity in LGMD2A patients with normal protein expression.Regulation and physiological roles of the calpain system in muscular disordersLoss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.Calpain 3: a key regulator of the sarcomere?Mechanistic role of calpains in postischemic neurodegeneration.Calpain 3, the "gatekeeper" of proper sarcomere assembly, turnover and maintenance.Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity.Calpain-3-mediated regulation of the Na⁺-Ca²⁺ exchanger isoform 3.Calpain 3 is activated through autolysis within the active site and lyses sarcomeric and sarcolemmal componentsPLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.The function of filensin and phakinin in lens transparency.Effect of exercise training on calpain systems in lean and obese Zucker rats.Homodimerization of calpain 3 penta-EF-hand domain.Release of skeletal muscle peptide fragments identifies individual proteins degraded during insulin deprivation in type 1 diabetic humans and mice.Characterization of a new p94-like calpain form in human lymphocytes.Calpain expression and activity during lens fiber cell differentiation.Identification of putative in vivo substrates of calpain 3 by comparative proteomics of overexpressing transgenic and nontransgenic mice.Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide.Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3.
P2860
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P2860
Expression and functional characteristics of calpain 3 isoforms generated through tissue-specific transcriptional and posttranscriptional events
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Expression and functional char ...... and posttranscriptional events
@ast
Expression and functional char ...... and posttranscriptional events
@en
type
label
Expression and functional char ...... and posttranscriptional events
@ast
Expression and functional char ...... and posttranscriptional events
@en
prefLabel
Expression and functional char ...... and posttranscriptional events
@ast
Expression and functional char ...... and posttranscriptional events
@en
P2093
P2860
P356
P1476
Expression and functional char ...... and posttranscriptional events
@en
P2093
D Montarras
D Stockholm
F Fougerousse
H Sorimachi
J S Beckmann
P2860
P304
P356
10.1128/MCB.19.6.4047
P407
P577
1999-06-01T00:00:00Z