Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. - Wikidata - wikimedia - TriplyDB

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

http://www.wikidata.org/entity/Q33653056

about

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis Trypanocidal activity of marine natural products Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes.Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.Synthesis and evaluation of indatraline-based inhibitors for trypanothione reductase Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488 Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.Evaluating 5-nitrofurans as trypanocidal agents.Whole-organism high-throughput screening against Trypanosoma brucei brucei.In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment.Quinol derivatives as potential trypanocidal agents Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.Identification and Characterization of FTY720 for the Treatment of Human African Trypanosomiasis.The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis Luminescent multiplex viability assay for Trypanosoma brucei gambiense.Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei.High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.Development of novel drugs for human African trypanosomiasis.Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?Drug discovery and human African trypanosomiasis: a disease less neglected?Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation.Development of a semi-automated image-based high-throughput drug screening system.The κ-opioid receptor agonist U-50488 blocks Ca2+ channels in a voltage- and G protein-independent manner in sensory neurons.Screening a Natural Product-Based Library against Kinetoplastid Parasites.Kappa opioid receptors regulate hippocampal synaptic homeostasis and epileptogenesis.Molecular characterization of latent GDF8 reveals mechanisms of activation.Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.Unravelling the role of SNM1 in the DNA repair system of Trypanosoma brucei.Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals

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Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

http://www.wikidata.org/entity/Q33653056

description

2010 nî lūn-bûn

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2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2010 թվականի օգոստոսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Identification of a κ-opioid a ...... human African trypanosomiasis.

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Identification of a κ-opioid a ...... human African trypanosomiasis.

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Identification of a κ-opioid a ...... human African trypanosomiasis.

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J.BCP.2010.07.038

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Biochemical Pharmacology

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Identification of a κ-opioid a ...... human African trypanosomiasis.

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Deuan C Jones

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Irene Hallyburton

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Julie A Frearson

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Kevin D Read

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Laste Stojanovski

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P2860

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

Basic local alignment search tool

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

Adriamycin, 14-hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius

Network pharmacology: the next paradigm in drug discovery

Chloroquine transport via the malaria parasite's chloroquine resistance transporter

Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.

Lessons learnt from assembling screening libraries for drug discovery for neglected diseases.

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

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10.1016/J.BCP.2010.07.038

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10

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80

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Alan H Fairlamb

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2010-08-07T00:00:00Z

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45582600

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20696141

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African trypanosomiasis

trypanosomiasis

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3025325

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