Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. - Wikidata - wikimedia - TriplyDB

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

http://www.wikidata.org/entity/Q34113517

about

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects A molecular mechanism for eflornithine resistance in African trypanosomes Fexinidazole: a potential new drug candidate for Chagas disease Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome Activation of Bicyclic Nitro-drugs by a Novel Nitroreductase (NTR2) in Leishmania Drug resistance in eukaryotic microorganisms.The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6.Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies.Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation Evaluating 5-nitrofurans as trypanocidal agents.Genetic dissection of drug resistance in trypanosomes From on-target to off-target activity: identification and optimisation of Trypanosoma brucei GSK3 inhibitors and their characterisation as anti-Trypanosoma brucei drug discovery lead molecules.Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.Antiparasitic chemotherapy: from genomes to mechanisms.Antitrypanosomal activity of fexinidazole, a new oral nitroimidazole drug candidate for treatment of sleeping sickness Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.A new approach to chemotherapy: drug-induced differentiation kills African trypanosomes.Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis ALDH2 mediates 5-nitrofuran activity in multiple species.Development of novel drugs for human African trypanosomiasis.Drug resistance in human African trypanosomiasis.Drug discovery for neglected diseases: molecular target-based and phenotypic approaches.Therapeutical approaches under investigation for treatment of Chagas disease.Investigational drugs for visceral leishmaniasis.Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei.Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation.A class of 5-nitro-2-furancarboxylamides with potent trypanocidal activity against Trypanosoma brucei in vitro.Trypanocidal activity of aziridinyl nitrobenzamide prodrugs.Therapeutic responses to different anti-Trypanosoma cruzi drugs in experimental infection by benznidazole-resistant parasite stock.Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism

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Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

http://www.wikidata.org/entity/Q34113517

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Cross-resistance to nitro drug ...... human African trypanosomiasis.

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Cross-resistance to nitro drug ...... human African trypanosomiasis.

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Cross-resistance to nitro drug ...... human African trypanosomiasis.

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type

label

Cross-resistance to nitro drug ...... human African trypanosomiasis.

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Cross-resistance to nitro drug ...... human African trypanosomiasis.

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Cross-resistance to nitro drug ...... human African trypanosomiasis.

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prefLabel

Cross-resistance to nitro drug ...... human African trypanosomiasis.

@ast

Cross-resistance to nitro drug ...... human African trypanosomiasis.

@en

Cross-resistance to nitro drug ...... human African trypanosomiasis.

@nl

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Antimicrobial Agents and Chemotherapy

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Cross-resistance to nitro drug ...... human African trypanosomiasis.

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Antoaneta Y Sokolova

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Kevin D Read

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Stephen Patterson

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P2860

Safety, tolerability, and pharmacokinetics of PA-824 in healthy subjects

The mechanism of action of PA-824: Novel insights from transcriptional profiling

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

Equivalence trial of melarsoprol and nifurtimox monotherapy and combination therapy for the treatment of second-stage Trypanosoma brucei gambiense sleeping sickness

Pathways of oxidative damage

The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes.

Treatment of human African trypanosomiasis--present situation and needs for research and development.

The use of the 2 substituted 5-nitroimidazole, Fexinidazole (Hoe 239) in the treatment of chronic T. brucei infections in mice.

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2893-2900

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10.1128/AAC.00332-10

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7

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54

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Alan H Fairlamb

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20439607

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African trypanosomiasis

trypanosomiasis

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2897277

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