about
Inflammatory process in Alzheimer's DiseaseSynaptic transmission block by presynaptic injection of oligomeric amyloid betaMicroglia and the immune pathology of Alzheimer disease.Transcriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREBThe γ-secretase complex: from structure to function.Calpain dysregulation in Alzheimer's diseasePresenilins regulate the cellular level of the tumor suppressor PTEN.Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease.The Alzheimer's disease beta-secretase enzyme, BACE1.Notch signaling in T-cell acute lymphoblastic leukemia.The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease.Early onset Alzheimer's disease and oxidative stress.A carboxylated Zn-phthalocyanine inhibits fibril formation of Alzheimer's amyloid β peptide.Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends.Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.Intracellular retention of caveolin 1 in presenilin-deficient cells.Pterostilbene ameliorates intracerebroventricular streptozotocin induced memory decline in rats.Human beta-secretase and Alzheimer's disease.Amyloid-beta levels are significantly reduced and spatial memory defects are rescued in a novel neuroserpin-deficient Alzheimer's disease transgenic mouse model.Analysis of the disease risk locus DXS1047 polymorphism in Brazilian Alzheimer patients.Expression of Notch pathway components in spermatogonia and Sertoli cells of neonatal mice.The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.The Presenilin loop region is essential for Glycogen synthase kinase 3 beta mediated functions on motor proteins during axonal transport.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Function and dysfunction of the presenilins
@ast
Function and dysfunction of the presenilins
@en
type
label
Function and dysfunction of the presenilins
@ast
Function and dysfunction of the presenilins
@en
prefLabel
Function and dysfunction of the presenilins
@ast
Function and dysfunction of the presenilins
@en
P2093
P2860
P356
P1476
Function and dysfunction of the presenilins
@en
P2093
G Thinakaran
S S Sisodia
P2860
P356
10.1086/302475
P407
P577
1999-07-01T00:00:00Z