Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
about
A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 proteinPresenilin 2 interacts with sorcin, a modulator of the ryanodine receptorPresenilin 1 is linked with gamma-secretase activity in the detergent solubilized stateCalsenilin reverses presenilin-mediated enhancement of calcium signalingSubstitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signalingMolecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signalingCellular localization of Nicastrin affects amyloid beta species productionSEL-10 interacts with presenilin 1, facilitates its ubiquitination, and alters A-beta peptide productionInteraction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer diseasePresenilin 1 associates with glycogen synthase kinase-3beta and its substrate tauGeneration of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavageCleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide productionPresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationAssociation of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrinThe presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residueHuman aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor proteinInteraction of presenilins with the filamin family of actin-binding proteinsPhosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosisModulation of statin-activated shedding of Alzheimer APP ectodomain by ROCKThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationStructural biology of presenilin 1 complexesAPP intracellular domain-WAVE1 pathway reduces amyloid-β production.Three-dimensional structure of human γ-secretaseComplex regulation of γ-secretase: from obligatory to modulatory subunitsAn atomic structure of human γ-secretaseVPS35 regulates cell surface recycling and signaling of dopamine receptor D1Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-cateninDirect interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell deathPresenilin 1 protein directly interacts with Bcl-2The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragmentsp35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interactionPresenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashionEndoproteolytic processing and stabilization of wild-type and mutant presenilinProteolytic processing of Alzheimer's β-amyloid precursor protein
P2860
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P2860
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
description
1996 nî lūn-bûn
@nan
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@ast
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@en
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@en-gb
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@nl
type
label
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@ast
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@en
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@en-gb
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@nl
prefLabel
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@ast
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@en
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@en-gb
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@nl
P2093
P3181
P1433
P1476
Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo
@en
P2093
C Nordstedt
D R Borchelt
F Davenport
G Thinakaran
P304
P3181
P356
10.1016/S0896-6273(00)80291-3
P407
P577
1996-07-01T00:00:00Z