Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. - Wikidata - wikimedia - TriplyDB

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.

http://www.wikidata.org/entity/Q33659512

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The transcription factor p53: not a repressor, solely an activator The expanding regulatory universe of p53 in gastrointestinal cancer Mechanisms of ferroptosis SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton p53 mutation status is a primary determinant of placenta-specific protein 1 expression in serous ovarian cancers.Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53 A promoter-proximal transcript targeted by genetic polymorphism controls E-cadherin silencing in human cancers.Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3 TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity A naturally occurring 4-bp deletion in the intron 4 of p53 creates a spectrum of novel p53 isoforms with anti-apoptosis function.Bystander communication and cell cycle decisions after DNA damage Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA.Whole-genome cartography of p53 response elements ranked on transactivation potential.Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis MAF1 represses CDKN1A through a Pol III-dependent mechanism Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial Cells Growth differentiation factor-15 encodes a novel microRNA 3189 that functions as a potent regulator of cell death.High-Resolution 4C Reveals Rapid p53-Dependent Chromatin Reorganization of the CDKN1A Locus in Response to Stress.p53 Specifically Binds Triplex DNA In Vitro and in Cells Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells.Knockout of Drosophila RNase ZL impairs mitochondrial transcript processing, respiration and cell cycle progression p53 attenuates AKT signaling by modulating membrane phospholipid composition Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres.Autoimmune vitiligo is associated with gain-of-function by a transcriptional regulator that elevates expression of HLA-A*02:01 in vivo.p53 Pulses Diversify Target Gene Expression Dynamics in an mRNA Half-Life-Dependent Manner and Delineate Co-regulated Target Gene Subnetworks.USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation.Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory Effects Primary cancer cell culture: mammary-optimized vs conditional reprogramming.Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements.Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis.The role of DNA damage responses in p53 biology.p53, a translational regulator: contribution to its tumour-suppressor activity.3,6-Diazaphenothiazines as potential lead molecules - synthesis, characterization and anticancer activity.Tumor-Suppressor Functions of the TP53 Pathway.p53-dependent non-coding RNA networks in chronic lymphocytic leukemia.A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.

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Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.

http://www.wikidata.org/entity/Q33659512

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Global analysis of p53-regulat ...... xpected regulatory mechanisms.

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Global analysis of p53-regulat ...... xpected regulatory mechanisms.

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Global analysis of p53-regulat ...... xpected regulatory mechanisms.

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Global analysis of p53-regulat ...... xpected regulatory mechanisms.

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Global analysis of p53-regulat ...... expected regulatory mechanisms

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Anna Guarnieri

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Hestia S Mellert

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Joaquin M Espinosa

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Justin A Freeman

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Mary Ann Allen

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Veronica L Dengler

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W Lee Kraus

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Xin Luo

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Zdenek Andrysik

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P2860

Differential expression analysis for sequence count data

A model for p53-induced apoptosis

Repression of p53-mediated transcription by MDM2: a dual mechanism

Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Regulation of p53 stability by Mdm2

WAF1, a potential mediator of p53 tumor suppression

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters

Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling

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10.7554/ELIFE.02200

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3

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Matthew D Galbraith

Kelly D Sullivan

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262682785

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