Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer
about
A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanismRate, affinity and calcium dependence of nitric oxide synthase isoform binding to the primary physiological regulator calmodulinPulsed electron paramagnetic resonance study of domain docking in neuronal nitric oxide synthase: the calmodulin and output state perspective.Mechanism of Nitric Oxide Synthase Regulation: Electron Transfer and Interdomain Interactions.A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains.Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains.Role of an isoform-specific serine residue in FMN-heme electron transfer in inducible nitric oxide synthase.Dissecting regulation mechanism of the FMN to heme interdomain electron transfer in nitric oxide synthases.Charge-pairing interactions control the conformational setpoint and motions of the FMN domain in neuronal nitric oxide synthase.The C-terminal domain of 4-hydroxyphenylacetate 3-hydroxylase from Acinetobacter baumannii is an autoinhibitory domain.Phosphorylation Controls Endothelial Nitric-oxide Synthase by Regulating Its Conformational Dynamics.Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis.
P2860
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P2860
Lys842 in neuronal nitric-oxide synthase enables the autoinhibitory insert to antagonize calmodulin binding, increase FMN shielding, and suppress interflavin electron transfer
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Lys842 in neuronal nitric-oxid ...... interflavin electron transfer
@ast
Lys842 in neuronal nitric-oxid ...... interflavin electron transfer
@en
type
label
Lys842 in neuronal nitric-oxid ...... interflavin electron transfer
@ast
Lys842 in neuronal nitric-oxid ...... interflavin electron transfer
@en
prefLabel
Lys842 in neuronal nitric-oxid ...... interflavin electron transfer
@ast
Lys842 in neuronal nitric-oxid ...... interflavin electron transfer
@en
P2093
P2860
P356
P1476
Lys842 in neuronal nitric-oxid ...... interflavin electron transfer
@en
P2093
Dennis J Stuehr
Elizabeth D Getzoff
Elsa D Garcin
Mohammad Mahfuzul Haque
Zhi-Wen Guan
P2860
P304
P356
10.1074/JBC.M109.000810
P407
P577
2009-11-30T00:00:00Z