about
Modeling, mutagenesis, and structural studies on the fully conserved phosphate-binding loop (loop 8) of triosephosphate isomerase: toward a new substrate specificityDesigned protein G core variants fold to native-like structures: Sequence selection by ORBIT tolerates variation in backbone specificationComputational design and experimental study of tighter binding peptides to an inactivated mutant of HIV-1 proteaseHIV-1 Protease Inhibitors from Inverse Design in the Substrate Envelope Exhibit Subnanomolar Binding to Drug-Resistant VariantsElectrostatic Contribution of Surface Charge Residues to the Stability of a Thermophilic Protein: Benchmarking Experimental and Predicted pKa ValuesIterative approach to computational enzyme designDe novo design of protein homo-oligomers with modular hydrogen-bond network-mediated specificityA self-consistent knowledge-based approach to protein designDesign, synthesis, and characterization of a novel hemoproteinA polar, solvent-exposed residue can be essential for native protein structureDe novo design of helical bundles as models for understanding protein folding and function.One- and two-body decomposable Poisson-Boltzmann methods for protein design calculations.Modulation of protein stability and aggregation properties by surface charge engineering.Computational tools for epitope vaccine design and evaluationParallel Computational Protein Design.Computational method to reduce the search space for directed protein evolution.Statistical theory for protein ensembles with designed energy landscapes.Computationally designed libraries of fluorescent proteins evaluated by preservation and diversity of function.The minimized dead-end elimination criterion and its application to protein redesign in a hybrid scoring and search algorithm for computing partition functions over molecular ensembles.A search for energy minimized sequences of proteinsGo-ing for the prediction of protein folding mechanismsAn efficient parallel algorithm for accelerating computational protein design.Consolidating critical binding determinants by noncyclic rearrangement of protein secondary structure.Specificity versus stability in computational protein designEnzyme-like proteins by computational designBackbone dependency further improves side chain prediction efficiency in the Energy-based Conformer Library (bEBL).Combining computational and experimental screening for rapid optimization of protein propertiesAccurate solution of multi-region continuum biomolecule electrostatic problems using the linearized Poisson-Boltzmann equation with curved boundary elements.A critical analysis of computational protein design with sparse residue interaction graphs.Exploring the origins of binding specificity through the computational redesign of calmodulin.Algorithm for backrub motions in protein design.Improving computational efficiency and tractability of protein design using a piecemeal approach. A strategy for parallel and distributed protein design.Multistate approaches in computational protein design.Development of a cytokine analog with enhanced stability using computational ultrahigh throughput screeningIncreasing protein stability using a rational approach combining sequence homology and structural alignment: Stabilizing the WW domain.Analysis of allosteric signal transduction mechanisms in an engineered fluorescent maltose biosensor.Synthetic Protein Switches: Theoretical and Experimental Considerations.Computational predictions of the mutant behavior of AraC.cOSPREY: A Cloud-Based Distributed Algorithm for Large-Scale Computational Protein Design.The EVB as a quantitative tool for formulating simulations and analyzing biological and chemical reactions.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Computational protein design.
@ast
Computational protein design.
@en
type
label
Computational protein design.
@ast
Computational protein design.
@en
prefLabel
Computational protein design.
@ast
Computational protein design.
@en
P1433
P1476
Computational protein design.
@en
P2093
P304
P356
10.1016/S0969-2126(99)80062-8
P577
1999-05-01T00:00:00Z