Specificity versus stability in computational protein design
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Structure-based Protocol for Identifying Mutations that Enhance Protein–Protein Binding AffinitiesControlled Protein Dimerization through Hybrid Coordination MotifsDesign and characterization of an enhanced repressor of human papillomavirus E2 proteinMetal-Mediated Affinity and Orientation Specificity in a Computationally Designed Protein HomodimerGet5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 ComplexStructural, kinetic, and thermodynamic studies of specificity designed HIV-1 proteaseImproving biophysical properties of a bispecific antibody scaffold to aid developabilityThe structure of the giant haemoglobin from Glossoscolex paulistusMultivariate PLS Modeling of Apicomplexan FabD-Ligand Interaction Space for Mapping Target-Specific Chemical Space and Pharmacophore FingerprintsConstruction of a genetic multiplexer to toggle between chemosensory pathways in Escherichia coliDesign of multi-specificity in protein interfacesOptimizing scoring function of protein-nucleic acid interactions with both affinity and specificity.Computational approaches for rational design of proteins with novel functionalitiesThe evolution of protein structures and structural ensembles under functional constraint.The role of negative selection in protein evolution revealed through the energetics of the native state ensemble.Statistical potentials for improved structurally constrained evolutionary models.Specificity in computational protein designThe Framework of Computational Protein Design.Achievements and Challenges in Computational Protein Design.Designing specific protein-protein interactions using computation, experimental library screening, or integrated methodsPositive and negative design in stability and thermal adaptation of natural proteinsTradeoff between stability and multispecificity in the design of promiscuous proteins.Computational design of antibody-affinity improvement beyond in vivo maturationModular control of cross-oligomerization: analysis of superstabilized Hsp90 homodimers in vivo.De novo self-assembling collagen heterotrimers using explicit positive and negative design.Thermodynamic stability of histone H3 is a necessary but not sufficient driving force for its evolutionary conservationComputational design of second-site suppressor mutations at protein-protein interfacesEvolution: a guide to perturb protein function and networksCharge-rich regions modulate the anti-aggregation activity of Hsp90.Proteins from an unevolved library of de novo designed sequences bind a range of small molecules.Design of protein-interaction specificity gives selective bZIP-binding peptides.Computational design of affinity and specificity at protein-protein interfacesComputational design of selective peptides to discriminate between similar PDZ domains in an oncogenic pathwayDesign of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences.Specificity quantification of biomolecular recognition and its implication for drug discovery.Specificity in molecular design: a physical framework for probing the determinants of binding specificity and promiscuity in a biological environment.Novel method for probing the specificity binding profile of ligands: applications to HIV protease.Progress in computational protein design.Amino-acid interactions in psychrophiles, mesophiles, thermophiles, and hyperthermophiles: insights from the quasi-chemical approximation.A de novo designed protein protein interface.
P2860
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P2860
Specificity versus stability in computational protein design
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Specificity versus stability in computational protein design
@ast
Specificity versus stability in computational protein design
@en
type
label
Specificity versus stability in computational protein design
@ast
Specificity versus stability in computational protein design
@en
prefLabel
Specificity versus stability in computational protein design
@ast
Specificity versus stability in computational protein design
@en
P2860
P356
P1476
Specificity versus stability in computational protein design
@en
P2093
Robert A Grant
Tania A Baker
P2860
P304
12724-12729
P356
10.1073/PNAS.0506124102
P407
P577
2005-08-29T00:00:00Z