A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway - Wikidata - wikimedia - TriplyDB

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway

http://www.wikidata.org/entity/Q33677437

about

INS-gene mutations: from genetics and beta cell biology to clinical disease Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues Conformational dynamics of insulin.Intracellular transport and secretion of salivary proteins.Expression and secretion of human proinsulin-B10 from mouse salivary glands: implications for the treatment of type I diabetes mellitus.Is dynamic autocrine insulin signaling possible? A mathematical model predicts picomolar concentrations of extracellular monomeric insulin within human pancreatic islets.Zinc transporters and their role in the pancreatic β-cell.A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells.A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cells Adaptation to supraphysiologic levels of insulin gene expression in transgenic mice: evidence for the importance of posttranscriptional regulation.A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).Zinc and human health: an update.Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene.Genetic engineering in mice: impact on insulin signalling and action.A fast response mechanism for insulin storage in crystals may involve kink generation by association of 2D clusters.Proinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathway Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells Topographic abnormalities of proinsulin to insulin conversion in functioning human insulinomas. Comparison of immunoelectron microscopic and clinical data.New roles of carboxypeptidase E in endocrine and neural function and cancer.Distinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells.Intracellular transport and sorting of mutant human proinsulins that fail to form hexamers.Protein targeting via the "constitutive-like" secretory pathway in isolated pancreatic islets: passive sorting in the immature granule compartment.Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes.Diabetes mellitus due to the toxic misfolding of proinsulin variants.Molecular Genetic Regulation of Slc30a8/ZnT8 Reveals a Positive Association With Glucose Tolerance.Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.Insulin granule biogenesis, trafficking and exocytosis.Overexpression of beta 2-microglobulin in transgenic mouse islet beta cells results in defective insulin secretion.Insulin therapy in diabetes and cancer risk: current understanding and implications for future study: proceedings from a meeting of a European Insulin Safety Consensus Panel, convened and sponsored by Novo Nordisk, held Tuesday October 5, 2010 at Th Insulin gene mutations and diabetes SLC30A8 mutations in type 2 diabetes.Distinct molecular events during secretory granule biogenesis revealed by sensitivities to brefeldin A.Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog.Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells.Behavior in the eukaryotic secretory pathway of insulin-containing fusion proteins and single-chain insulins bearing various B-chain mutations.Sorting and storage during secretory granule biogenesis: looking backward and looking forward.Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility.Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.

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P2860

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway

http://www.wikidata.org/entity/Q33677437

description

1988 nî lūn-bûn

@nan

1988 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

1988 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

1988年の論文

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1988年論文

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1988年論文

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1988年論文

@zh-hk

1988年論文

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1988年論文

@zh-tw

1988年论文

@wuu

name

A mutant human proinsulin is s ...... nts via an unregulated pathway

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A mutant human proinsulin is s ...... nts via an unregulated pathway

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type

label

A mutant human proinsulin is s ...... nts via an unregulated pathway

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A mutant human proinsulin is s ...... nts via an unregulated pathway

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prefLabel

A mutant human proinsulin is s ...... nts via an unregulated pathway

@ast

A mutant human proinsulin is s ...... nts via an unregulated pathway

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PNAS.85.23.8943

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Proceedings of the National Academy of Sciences of the United States of America

P1476

A mutant human proinsulin is s ...... nts via an unregulated pathway

@en

P2093

A H Rubenstein

http://www.w3.org/2001/XMLSchema#string

D F Steiner

http://www.w3.org/2001/XMLSchema#string

H H Swift

http://www.w3.org/2001/XMLSchema#string

R E Hammer

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R J Carroll

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S J Chan

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P2860

Studies on the secretion of newly synthesized proinsulin and insulin from isolated rat islets of Langerhans.

A superactive insulin: [B10-aspartic acid]insulin(human).

Familial hyperproinsulinemia. Two cohorts secreting indistinguishable type II intermediates of proinsulin conversion.

A mutation in the B chain coding region is associated with impaired proinsulin conversion in a family with hyperproinsulinemia.

Retention and degradation of 125I-insulin by perfused livers from diabetic rats.

Pancreatic expression of human insulin gene in transgenic mice.

Quantitative study of insulin secretion and clearance in normal and obese subjects

Preparation and characterization of plasma membrane-enriched fractions from rat pancreatic islets.

Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

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scholarly article

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10.1073/PNAS.85.23.8943

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23

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85

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1988-12-01T00:00:00Z

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20097780

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3057496

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282623

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