X-ray structure of human aromatase reveals an androgen-specific active site
about
The structural biology of oestrogen metabolismStructural diversity of eukaryotic membrane cytochrome p450sNovel Aromatase Inhibitors by Structure-Guided DesignThe role of Ile87 of CYP158A2 in oxidative coupling reactionStructural Basis for the Functional Roles of Critical Residues in Human Cytochrome P450 AromataseAromatase deficiency in a Chinese adult man caused by novel compound heterozygous CYP19A1 mutations: effects of estrogen replacement therapy on the bone, lipid, liver and glucose metabolism.Modelling inhibition of avian aromatase by azole pesticides.Kinetic solvent isotope effect in steady-state turnover by CYP19A1 suggests involvement of Compound 1 for both hydroxylation and aromatization steps.Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variantsNatural compounds with aromatase inhibitory activity: an update.CYP2C8 exists as a dimer in natural membranes.Mechanism of inhibition of estrogen biosynthesis by azole fungicides.Evolutionary origins of the estrogen signaling system: insights from amphioxusBinding features of steroidal and nonsteroidal inhibitorsConvenient method for the functionalization of the 4- and 6-positions of the androgen skeleton.Structural and functional characterization of aromatase, estrogen receptor, and their genes in endocrine-responsive and -resistant breast cancer cells.Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.Synthesis and structure-activity relationship studies of derivatives of the dual aromatase-sulfatase inhibitor 4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamateMolecular simulations of aromatase reveal new insights into the mechanism of ligand binding.Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase InhibitorsInstability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.Genetic and structural analyses of cytochrome P450 hydroxylases in sex hormone biosynthesis: Sequential origin and subsequent coevolution.The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines MechanismTamoxifen metabolites as active inhibitors of aromatase in the treatment of breast cancer.3D-QSAR study of steroidal and azaheterocyclic human aromatase inhibitors using quantitative profile of protein-ligand interactions.Testosterone complex and non-steroidal ligands of human aromatase.Ligand Access Channels in Cytochrome P450 Enzymes: A Review.Aromatase, aromatase inhibitors, and breast cancer
P2860
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P2860
X-ray structure of human aromatase reveals an androgen-specific active site
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
X-ray structure of human aromatase reveals an androgen-specific active site
@ast
X-ray structure of human aromatase reveals an androgen-specific active site
@en
type
label
X-ray structure of human aromatase reveals an androgen-specific active site
@ast
X-ray structure of human aromatase reveals an androgen-specific active site
@en
prefLabel
X-ray structure of human aromatase reveals an androgen-specific active site
@ast
X-ray structure of human aromatase reveals an androgen-specific active site
@en
P2093
P2860
P1476
X-ray structure of human aromatase reveals an androgen-specific active site
@en
P2093
Debashis Ghosh
Jennifer Griswold
Mary Erman
Walter Pangborn
P2860
P304
P356
10.1016/J.JSBMB.2009.09.012
P577
2009-10-04T00:00:00Z