Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.

Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.

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http://www.wikidata.org/entity/Q33685192
How special is the biochemical function of native proteins?Modeling enzyme-ligand binding in drug discoveryImplications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical functionTemplate-based prediction of protein functionPoLi: A Virtual Screening Pipeline Based on Template Pocket and Ligand Similarity.Why Is There a Glass Ceiling for Threading Based Protein Structure Prediction Methods?Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.On the importance of composite protein multiple ligand interactions in protein pockets.Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors.Catalytic and substrate promiscuity: distinct multiple chemistries catalysed by the phosphatase domain of receptor protein tyrosine phosphatase.Comprehensive prediction of drug-protein interactions and side effects for the human proteome.Repurposing FDA-approved drugs for anti-aging therapies.Novel small molecule binders of human N-glycanase 1, a key player in the endoplasmic reticulum associated degradation pathway.Rational Design of Novel Allosteric Dihydrofolate Reductase Inhibitors Showing Antibacterial Effects on Drug-Resistant Escherichia coli Escape Variants.Pocket detection and interaction-weighted ligand-similarity search yields novel high-affinity binders for Myocilin-OLF, a protein implicated in glaucoma.
P2860

Experimental validation of FINDSITE(comb) virtual ligand screening results for eight proteins yields novel nanomolar and micromolar binders.

Item
http://www.wikidata.org/entity/Q33685192
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Experimental validation of FIN ...... omolar and micromolar binders.
@ast
Experimental validation of FIN ...... omolar and micromolar binders.
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label
Experimental validation of FIN ...... omolar and micromolar binders.
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Experimental validation of FIN ...... omolar and micromolar binders.
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prefLabel
Experimental validation of FIN ...... omolar and micromolar binders.
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Experimental validation of FIN ...... omolar and micromolar binders.
@en
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P478
P50
P577
P5875
P6179
P698
P932
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P1476
Experimental validation of FIN ...... omolar and micromolar binders.
@en
P2093
P2860
P2888
P304
P31
P356
P478
P50
P577
P5875
P6179
P698
P932