The regulation of the p53-mediated stress response by MDM2 and MDM4.
about
Protein degradation and the stress responsep53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening systemExploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growthFunctional activation of mutant p53V172F by platinum analogs in cisplatin-resistant human tumor cells is dependent on serine-20 phosphorylationMouse models of p53 functions.Low levels of p53 protein and chromatin silencing of p53 target genes repress apoptosis in Drosophila endocycling cells.p53 Research: the past thirty years and the next thirty years.p53 Family and Cellular Stress Responses in Cancer.LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity.Recombinant human MFG-E8 attenuates intestinal injury and mortality in severe whole body irradiation in ratsGenetic variation in MDM2 and p14ARF and susceptibility to salivary gland carcinoma.MicroRNA-339-5p inhibits colorectal tumorigenesis through regulation of the MDM2/p53 signaling.Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage.Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish.Downregulation of Mdm2 and Mdm4 enhances viral gene expression during adenovirus infection.Resistant starches protect against colonic DNA damage and alter microbiota and gene expression in rats fed a Western dietAssociation of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle.Important genes in the pathogenesis of 5q- syndrome and their connection with ribosomal stress and the innate immune system pathway.The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.Distinct downstream targets manifest p53-dependent pathologies in mice.Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis.Genetic and epigenetic mutations of tumor suppressive genes in sporadic pituitary adenomaHeterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53.Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.Interference with p53 functions in human viral infections, a target for novel antiviral strategies?Ubiquitination and the Ubiquitin-Proteasome System as regulators of transcription and transcription factors in epithelial mesenchymal transition of cancer.p53 mRNA and p53 Protein Structures Have Evolved Independently to Interact with MDM2.Partial p53-dependence of anisomycin-induced apoptosis in PC12 cells.Major apoptotic mechanisms and genes involved in apoptosis.p53 signaling pathway polymorphisms, cancer risk and tumor phenotype in TP53 R337H mutation carriers.A Functional Polymorphism (rs937283) in the MDM2 Promoter Region is Associated with Poor Prognosis of Retinoblastoma in Chinese Han Population.Potential therapeutic targets of TP53 gene in the context of its classically canonical functions and its latest non-canonical functions in human cancer.Human Oncoviruses and p53 Tumor Suppressor Pathway Deregulation at the Origin of Human Cancers.Apoptosis in inner ear sensory hair cells.The Roles of MDM2 and MDMX in Cancer.Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke
P2860
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P2860
The regulation of the p53-mediated stress response by MDM2 and MDM4.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The regulation of the p53-mediated stress response by MDM2 and MDM4.
@ast
The regulation of the p53-mediated stress response by MDM2 and MDM4.
@en
type
label
The regulation of the p53-mediated stress response by MDM2 and MDM4.
@ast
The regulation of the p53-mediated stress response by MDM2 and MDM4.
@en
prefLabel
The regulation of the p53-mediated stress response by MDM2 and MDM4.
@ast
The regulation of the p53-mediated stress response by MDM2 and MDM4.
@en
P2860
P1476
The regulation of the p53-mediated stress response by MDM2 and MDM4.
@en
P2093
Mary Ellen Perry
P2860
P304
P356
10.1101/CSHPERSPECT.A000968
P577
2010-01-01T00:00:00Z