MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
about
Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activityGenomic subtypes of breast cancer identified by array-comparative genomic hybridization display distinct molecular and clinical characteristicsApoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategiesAlterations in Mitochondrial and Endoplasmic Reticulum Signaling by p53 MutantsThe Double Role of p53 in Cancer and Autoimmunity and Its Potential as Therapeutic TargetTwo strategies for the development of mitochondrion-targeted small molecule radiation damage mitigatorsMDM2 and MDMX: Alone and together in regulation of p53Tumor suppressor p53 and estrogen receptors in nuclear-mitochondrial communication.The regulation of the p53-mediated stress response by MDM2 and MDM4.microRNAs and Alu elements in the p53-Mdm2-Mdm4 regulatory network.The p53 orchestra: Mdm2 and Mdmx set the tonePhospho-ΔNp63α/miR-885-3p axis in tumor cell life and cell death upon cisplatin exposure.Hypoxia Promotes Synergy between Mitomycin C and Bortezomib through a Coordinated Process of Bcl-xL Phosphorylation and Mitochondrial Translocation of p53.MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage responsep63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.Novel insights about the MDM2/MDM4 heterodimer.The Hsp90 inhibitor 17-(allylamino)-17-demethoxygeldanamycin increases cisplatin antitumor activity by inducing p53-mediated apoptosis in head and neck cancer.MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability.p53-family proteins and their regulators: hubs and spokes in tumor suppression.The relevance of protein-protein interactions for p53 function: the CPE contribution.Functions of MDMX in the modulation of the p53-response.Regulation of anti-apoptotic BCL2-proteins by non-canonical interactions: the next step forward or two steps back?The cytoplasmic side of p53's oncosuppressive activities.Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondriaMitochondrial death functions of p53.The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.MDMX (MDM4), a Promising Target for p53 Reactivation Therapy and Beyond.Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma.Cisplatin causes cell death via TAB1 regulation of p53/MDM2/MDMX circuitry.The prolyl-isomerase Pin1 activates the mitochondrial death program of p53Identification of ribosomal protein S25 (RPS25)-MDM2-p53 regulatory feedback loop.Directing p53 to induce autophagySerine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis.Mdmx: a p53 activator?The Roles of MDM2 and MDMX in Cancer.Regulation of Apoptosis During Porcine Circovirus Type 2 Infection
P2860
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P2860
MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@ast
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@en
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@en-gb
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@nl
type
label
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@ast
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@en
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@en-gb
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@nl
prefLabel
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@ast
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@en
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@en-gb
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@nl
P2093
P2860
P50
P3181
P356
P1433
P1476
MDM4 (MDMX) localizes at the m ...... ed intrinsic-apoptotic pathway
@en
P2093
Alfredo Pontecorvi
Andrea Prodosmo
Antonio Marchetti
Fiamma Buttitta
Fulvio Florenzano
Giusy Di Conza
Lara Felicioni
P2860
P304
P3181
P356
10.1038/EMBOJ.2009.154
P407
P50
P5008
P577
2009-07-08T00:00:00Z