Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.
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Regulation of Bim in Health and DiseaseGLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein BimCytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activationp53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stressRole of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiencyExposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cellsBH3-only molecule Bim mediates β-cell death in IRS2 deficiency.Nova1 is a master regulator of alternative splicing in pancreatic beta cells.High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeletonAge-related changes in insulin sensitivity and β-cell function among European-American and African-American women.Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.Pancreatic Alpha Cells Hold the Key to SurvivalTranscriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axisMercuric compounds induce pancreatic islets dysfunction and apoptosis in vivop53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways.Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak.Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarmingBH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes.Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes.Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasisLinking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetesThe proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicityCystic fibrosis related diabetes (CFRD)--the end stage of progressive insulin deficiency.BCL-2 family of proteins and mammary cellular fate.The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis.The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes.Innovative Microcapsules for Pancreatic β-Cells Harvested from Mature Double-Transgenic Mice: Cell Imaging, Viability, Induced Glucose-Stimulated Insulin Measurements and Proinflammatory Cytokines Analysis.Diagnosing cystic fibrosis-related diabetes: current methods and challenges.PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells.High Recovery of Functional Islets Stored at Low and Ultralow Temperatures.The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival.Intracellular pathways of pancreatic β-cell apoptosis in type 1 diabetes.An optimized protocol for purification of functional islets of Langerhans.Systematic review of islet cryopreservation.GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus.
P2860
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P2860
Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.
@ast
Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.
@en
type
label
Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.
@ast
Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.
@en
prefLabel
Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.
@ast
Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.
@en
P2093
P2860
P50
P356
P1433
P1476
Glucose induces pancreatic isl ...... nd multi-BH domain protein Bax
@en
P2093
Clare L Scott
Elisa S Jansen
Emma Jamieson
Helen E Thomas
Janette Allison
Mark D McKenzie
Thomas W H Kay
P2860
P304
P356
10.2337/DB09-1151
P407
P577
2009-12-03T00:00:00Z