Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. - Wikidata - wikimedia - TriplyDB

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

http://www.wikidata.org/entity/Q33688622

about

Regulation of Bim in Health and Disease GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress Role of BH3-only molecules Bim and Puma in β-cell death in Pdx1 deficiency Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim.The transcription factor C/EBP delta has anti-apoptotic and anti-inflammatory roles in pancreatic beta cells BH3-only molecule Bim mediates β-cell death in IRS2 deficiency.Nova1 is a master regulator of alternative splicing in pancreatic beta cells.High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeleton Age-related changes in insulin sensitivity and β-cell function among European-American and African-American women.Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets.Lipotoxic Stress Induces Pancreatic β-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System.cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets.Pancreatic Alpha Cells Hold the Key to Survival Transcriptome of pancreas-specific Bmpr1a-deleted islets links to TPH1-5-HT axis Mercuric compounds induce pancreatic islets dysfunction and apoptosis in vivo p53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity.Cardiac arrest triggers hippocampal neuronal death through autophagic and apoptotic pathways.Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak.Involvement of a proapoptotic gene (BBC3) in islet injury mediated by cold preservation and rewarming BH3-Only protein bmf is required for the maintenance of glucose homeostasis in an in vivo model of HNF1α-MODY diabetes.Phospho-BAD BH3 mimicry protects β cells and restores functional β cell mass in diabetes.Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetes The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity Cystic fibrosis related diabetes (CFRD)--the end stage of progressive insulin deficiency.BCL-2 family of proteins and mammary cellular fate.The role of reactive oxygen species and proinflammatory cytokines in type 1 diabetes pathogenesis.The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes.Innovative Microcapsules for Pancreatic β-Cells Harvested from Mature Double-Transgenic Mice: Cell Imaging, Viability, Induced Glucose-Stimulated Insulin Measurements and Proinflammatory Cytokines Analysis.Diagnosing cystic fibrosis-related diabetes: current methods and challenges.PAK1 limits the expression of the pro-apoptotic protein Bad in pancreatic islet β-cells.High Recovery of Functional Islets Stored at Low and Ultralow Temperatures.The esoteric roles of Bcl-2 family proteins in glucose homeostasis and cell survival.Intracellular pathways of pancreatic β-cell apoptosis in type 1 diabetes.An optimized protocol for purification of functional islets of Langerhans.Systematic review of islet cryopreservation.GLIS3 rs7020673 and rs10758593 polymorphisms interact in the susceptibility for type 1 diabetes mellitus.

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P2860

Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax.

http://www.wikidata.org/entity/Q33688622

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.

@ast

Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.

@en

type

label

Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.

@ast

Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.

@en

prefLabel

Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.

@ast

Glucose induces pancreatic isl ...... d multi-BH domain protein Bax.

@en

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Glucose induces pancreatic isl ...... nd multi-BH domain protein Bax

@en

P2093

Clare L Scott

http://www.w3.org/2001/XMLSchema#string

Elisa S Jansen

http://www.w3.org/2001/XMLSchema#string

Emma Jamieson

http://www.w3.org/2001/XMLSchema#string

Helen E Thomas

http://www.w3.org/2001/XMLSchema#string

Janette Allison

http://www.w3.org/2001/XMLSchema#string

Mark D McKenzie

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Thomas W H Kay

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P2860

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

The BCL-2 protein family: opposing activities that mediate cell death

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644-652

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scholarly article

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10.2337/DB09-1151

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3

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59

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Andreas Strasser

Philippe Bouillet

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2009-12-03T00:00:00Z

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40446756

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19959756

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2828664

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