Re-examining how complexin inhibits neurotransmitter release.
about
Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solutionSNARE zipperingComplexins: small but capableReconstituting SNARE-mediated membrane fusion at the single liposome level.Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndromeComplexin inhibits spontaneous release and synchronizes Ca2+-triggered synaptic vesicle fusion by distinct mechanismsThe accessory helix of complexin functions by stabilizing central helix secondary structureRe-visiting the trans insertion model for complexin clamping.Munc18a does not alter fusion rates mediated by neuronal SNAREs, synaptotagmin, and complexinMolecular underpinnings of synaptic vesicle pool heterogeneity.Three steps forward, two steps back: mechanistic insights into the assembly and disassembly of the SNARE complex.Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complexN-terminal domain of complexin independently activates calcium-triggered fusion.C-terminal domain of mammalian complexin-1 localizes to highly curved membranes.Complexin splits the membrane-proximal region of a single SNAREpin.Preincubation of t-SNAREs with Complexin I Increases Content-Mixing Efficiency.The proteins of exocytosis: lessons from the sperm model.Chaperoning SNARE assembly and disassemblyThe Multifaceted Role of SNARE Proteins in Membrane Fusion.Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes.Reconciling isothermal titration calorimetry analyses of interactions between complexin and truncated SNARE complexes.Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function.Interaction of the Complexin Accessory Helix with Synaptobrevin Regulates Spontaneous Fusion.Complexin Binding to Membranes and Acceptor t-SNAREs Explains Its Clamping Effect on Fusion.A mechanism for exocytotic arrest by the Complexin C-terminusMechanism of neurotransmitter release coming into focusFocused clamping of a single neuronal SNARE complex by complexin under high mechanical tension
P2860
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P2860
Re-examining how complexin inhibits neurotransmitter release.
description
2014 nî lūn-bûn
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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2014 թվականի մայիսին հրատարակված գիտական հոդված
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2014年の論文
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2014年学术文章
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2014年学术文章
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2014年学术文章
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2014年学术文章
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name
Re-examining how complexin inhibits neurotransmitter release.
@ast
Re-examining how complexin inhibits neurotransmitter release.
@en
type
label
Re-examining how complexin inhibits neurotransmitter release.
@ast
Re-examining how complexin inhibits neurotransmitter release.
@en
prefLabel
Re-examining how complexin inhibits neurotransmitter release.
@ast
Re-examining how complexin inhibits neurotransmitter release.
@en
P2860
P50
P356
P1433
P1476
Re-examining how complexin inhibits neurotransmitter release.
@en
P2093
David Flaherty
P2860
P304
P356
10.7554/ELIFE.02391
P407
P577
2014-05-08T00:00:00Z