Factors determining the selection of organic reactions by medicinal chemists and the use of these reactions in arrays (small focused libraries).
about
Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?Inside the mind of a medicinal chemist: the role of human bias in compound prioritization during drug discoveryA Functional Group Approach for Prediction of APPI Response of Organic Synthetic Targets.Fragment-based domain shuffling approach for the synthesis of pyran-based macrocycles.Synthesis of a stereochemically diverse library of medium-sized lactams and sultams via S(N)Ar cycloetherification.Application of a sparse matrix design strategy to the synthesis of dos libraries.Towards the systematic exploration of chemical space.Replacing conventional carbon nucleophiles with electrophiles: nickel-catalyzed reductive alkylation of aryl bromides and chloridesSynthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.A chemogenomic analysis of ionization constants--implications for drug discoveryElectrophile induced branching cascade: a powerful approach to access various molecular scaffolds and their exploration as novel anti-mycobacterial agents.Challenging nickel-catalysed amine arylations enabled by tailored ancillary ligand design.Cross-coupling in flow.The influence of the 'organizational factor' on compound quality in drug discovery.Lead-oriented synthesis: a new opportunity for synthetic chemistry.A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds.Industrial applications of the Diels-Alder reaction.Selection of boron reagents for Suzuki-Miyaura coupling.Pharmaceuticals that contain polycyclic hydrocarbon scaffolds.A Combined Experimental/Computational Study of the Mechanism of a Palladium-Catalyzed Bora-Negishi Reaction.Modern advances in heterocyclic chemistry in drug discovery.Applications of Palladium-Catalyzed C-N Cross-Coupling Reactions.Nickel-catalyzed cross-electrophile coupling of 2-chloropyridines with alkyl bromides.Borate esters: Simple catalysts for the sustainable synthesis of complex amides.Biaryl Phosphine Based Pd(II) Amido Complexes: The Effect of Ligand Structure on Reductive Elimination.Scope of the palladium-catalyzed aryl borylation utilizing bis-boronic acid.Asymmetric Suzuki-Miyaura coupling of heterocycles via Rhodium-catalysed allylic arylation of racemates.Activity-Directed Synthesis with Intermolecular Reactions: Development of a Fragment into a Range of Androgen Receptor Agonists.Combining organometallic reagents, the sulfur dioxide surrogate DABSO, and amines: a one-pot preparation of sulfonamides, amenable to array synthesis.Relay catalytic branching cascade: a technique to access diverse molecular scaffolds.Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.Photoinduced Cycloadditions in the Diversity-Oriented Synthesis Toolbox: Increasing Complexity with Straightforward Postphotochemical Modifications.Selective Synthesis of Six Products from a Single Indolyl α-Diazocarbonyl Precursor.Nickel-catalyzed N-vinylation of heteroaromatic amines via C-H bond activation.A simple iridicycle catalyst for efficient transfer hydrogenation of N-heterocycles in water.Dihydrolevoglucosenone (Cyrene) as a bio-based alternative for dipolar aprotic solvents.Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple).Asymmetric cross-coupling of alkyl, alkenyl and (hetero)aryl nucleophiles with racemic allyl halides.Efficient discovery of bioactive scaffolds by activity-directed synthesis.Origin of the enantioselectivity in organocatalytic Michael additions of β-ketoamides to α,β-unsaturated carbonyls: a combined experimental, spectroscopic and theoretical study.
P2860
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P2860
Factors determining the selection of organic reactions by medicinal chemists and the use of these reactions in arrays (small focused libraries).
description
2010 nî lūn-bûn
@nan
2010 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Factors determining the select ...... ays (small focused libraries).
@ast
Factors determining the select ...... ays (small focused libraries).
@en
type
label
Factors determining the select ...... ays (small focused libraries).
@ast
Factors determining the select ...... ays (small focused libraries).
@en
prefLabel
Factors determining the select ...... ays (small focused libraries).
@ast
Factors determining the select ...... ays (small focused libraries).
@en
P2093
P356
P1476
Factors determining the select ...... ays (small focused libraries).
@en
P2093
Ian B Campbell
Simon J F Macdonald
Tony W J Cooper
P304
P356
10.1002/ANIE.201002238
P407
P577
2010-10-01T00:00:00Z