Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia.
about
Mitochondrial apoptosis and BH3 mimeticsEmerging therapies for acute myeloid leukemia.Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies.Rational combination strategies to enhance venetoclax activity and overcome resistance in hematologic malignancies.Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.Novel Therapies for Acute Myeloid Leukemia: Are We Finally Breaking the Deadlock?Novel investigational drugs active as single agents in multiple myeloma.What are the latest advancements in acute myeloid leukemia therapy?Biology and relevance of human acute myeloid leukemia stem cells.Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia.Quantitative Prediction of the Effect of CYP3A Inhibitors and Inducers on Venetoclax Pharmacokinetics Using a Physiologically Based Pharmacokinetic Model.Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax.Therapeutic inhibition of BCL-2 and related family members.Evaluation of the Pharmacokinetic Interaction between Venetoclax, a Selective BCL-2 Inhibitor, and Warfarin in Healthy Volunteers.Treatment of Relapsed/Refractory Acute Myeloid Leukemia.Effect of ketoconazole, a strong CYP3A inhibitor, on the pharmacokinetics of venetoclax, a BCL-2 inhibitor, in patients with non-Hodgkin lymphoma.Targeting anti-apoptotic BCL2 family proteins in haematological malignancies - from pathogenesis to treatment.The influential role of BCL2 family members in synovial sarcomagenesis.Impact of Venetoclax Exposure on Clinical Efficacy and Safety in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia.Venetoclax does not prolong the QT interval in patients with hematological malignancies: an exposure-response analysis.Molecular targeting in acute myeloid leukemiaEmerging therapies for acute myeloid leukemia: translating biology into the clinic.Targeting apoptosis in acute myeloid leukaemia.Moving Beyond Maximum Tolerated Dose for Targeted Oncology Drugs: Use of Clinical Utility Index to Optimize Venetoclax Dosage in Multiple Myeloma Patients.High-throughput profiling of signaling networks identifies mechanism-based combination therapy to eliminate microenvironmental resistance in acute myeloid leukemia.Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax.Effect of Low- and High-Fat Meals on the Pharmacokinetics of Venetoclax, a Selective First-in-Class BCL-2 Inhibitor.Evaluation of Rifampin's Transporter Inhibitory and CYP3A Inductive Effects on the Pharmacokinetics of Venetoclax, a BCL-2 Inhibitor: Results of a Single- and Multiple-Dose Study.Older Patients With Acute Myeloid Leukemia: Treatment Challenges and Future Directions.Why do BCL-2 inhibitors work and where should we use them in the clinic?The BCL-2 arbiters of apoptosis and their growing role as cancer targets.T-PLL: another check on the venetoclax list?A concise review of BCL-2 inhibition in acute myeloid leukemia.Glioblastoma and acute myeloid leukemia: malignancies with striking similarities.Clinical evaluation of P-glycoprotein inhibition by venetoclax: a drug interaction study with digoxin.Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration.Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.Wild-type and mutated IDH1/2 enzymes and therapy responses.Treatment of relapsed/refractory acute myeloid leukaemia in adults.Targeted therapies in Acute Myeloid Leukemia: a focus on FLT-3 inhibitors and ABT199.
P2860
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P2860
Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia.
description
2016 nî lūn-bûn
@nan
2016 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
Efficacy and Biological Correl ...... th Acute Myelogenous Leukemia.
@ast
Efficacy and Biological Correl ...... th Acute Myelogenous Leukemia.
@en
type
label
Efficacy and Biological Correl ...... th Acute Myelogenous Leukemia.
@ast
Efficacy and Biological Correl ...... th Acute Myelogenous Leukemia.
@en
prefLabel
Efficacy and Biological Correl ...... th Acute Myelogenous Leukemia.
@ast
Efficacy and Biological Correl ...... th Acute Myelogenous Leukemia.
@en
P2093
P2860
P50
P1433
P1476
Efficacy and Biological Correl ...... th Acute Myelogenous Leukemia.
@en
P2093
Ahmed Hamed Salem
Anthony Letai
Brenda Chyla
Courtney D DiNardo
Daniel A Pollyea
Evelyn McKeegan
Jalaja Potluri
Joel Leverson
Justin L Ricker
Leah Hogdal
P2860
P304
P356
10.1158/2159-8290.CD-16-0313
P577
2016-08-12T00:00:00Z