The BCL-2 arbiters of apoptosis and their growing role as cancer targets. - Wikidata - wikimedia - TriplyDB

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

http://www.wikidata.org/entity/Q47166330

about

Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview.Bcl-2 on the brink of breakthroughs in cancer treatment.Oncosuppressors and Oncogenes: Role in Haemangioma Genesis and Potential for Therapeutic Targeting.Synergistic anti-proliferative effects of combination of ABT-263 and MCL-1 selective inhibitor A-1210477 on cervical cancer cell lines.Pulling the BAX trigger for tumor cell death.BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose.Exploring the Structure-Activity Relationship and Mechanism of a Chromene Scaffold (CXL Series) for Its Selective Antiproliferative Activity toward Multidrug-Resistant Cancer Cells Nonproteinogenic deep mutational scanning of linear and cyclic peptides BH3 mimetics induce apoptosis independent of DRP-1 in melanoma Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells

P2860

Q47260956-CEA9F483-4A85-401D-A7A9-DAF829F8EDA9 Q49941394-37233F42-83AA-4750-AF56-377802261CC0 Q53693166-8473879C-C2F4-47A2-A8EC-B671BA255AC4 Q54985966-70CE893C-7A3F-49F2-B7D9-A9A69AA2E8A5 Q55234523-EE4373B6-5F48-439C-8B57-F7AF759491EA Q55474292-C82DAC90-DFD3-40FB-A43E-CEBB0C9298A5 Q57170103-8CD7B46D-9237-40A2-91A1-44B1D3958ABC Q57292178-3902A1C0-91C6-465A-B624-2A0F516AE140 Q58763373-66806EEC-0BAC-4296-9535-CB69420F0A8C Q58799845-719C4C75-9A55-4C3D-BC82-AC5C7D00E41A

P2860

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

http://www.wikidata.org/entity/Q47166330

description

2017 nî lūn-bûn

@nan

2017年の論文

@ja

2017年学术文章

@wuu

2017年学术文章

@zh

2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

@zh-sg

2017年學術文章

@yue

2017年學術文章

@zh-hant

name

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

@en

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

@nl

type

label

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

@en

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

@nl

prefLabel

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

@en

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

@nl

P1433

Q47166330-678D7D13-2634-45BA-A842-DA29B3B3A970

P1476

Q47166330-B1505F1E-0F4D-4FE3-9B88-03642792F501

P275

Q47166330-DE52E889-DAC4-4726-BD9C-BEF93CC5D11D

P2860

Q47166330-029058D3-0479-4468-BFA0-276DE3A4FAF3

Q47166330-02D649B4-E681-4C4B-9CB5-121622290D2A

Q47166330-06D6D6EC-8B2C-4219-A18F-0ED6E856CB0A

Q47166330-0AEF8D24-F818-4996-99FA-ED3E74AF0C0D

Q47166330-0F45FA91-0A68-47C9-A300-257E443AE874

Q47166330-11F7CC88-E1FF-46EE-9202-7FACF1524B8E

Q47166330-12E31A40-12A9-43D5-9A06-9796801605A0

Q47166330-143B385F-6665-487E-B75F-0F39764C8056

Q47166330-15012D21-4EF1-409D-B7E9-156FCDC7C277

Q47166330-1A53D46F-648F-4335-B905-86E193CE76AE

P2888

Q47166330-67BE198C-172B-4572-8DD6-68F076566415

P304

Q47166330-E5DBC6BB-45C0-4A54-92D2-81D68E030489

P31

Q47166330-539EADBC-B25B-4B64-9F3E-27820DB6061B

Q47166330-E4D43D8F-FAE4-4AD4-AE33-91D88C05A72A

P356

Q47166330-AB180041-FE4B-400B-B2A2-3E73811AD050

P433

Q47166330-C36272FA-C349-4006-8FD3-447F5842723F

P478

Q47166330-413C6D5B-3621-4409-94B2-5211C828E308

P50

Q47166330-06D91E89-D8FA-47F8-BB7E-DF0EE82986F9

Q47166330-B5C0485F-5AC2-4AD8-A9EB-39C51B9BE99B

P577

Q47166330-635906E5-654B-4C1C-9654-08DF617FE252

Q47166330-CBA76A75-5F74-42CD-96DF-52FA19EC0CBC

P698

Q47166330-89512951-2E3D-4D61-8E60-10E448B340FD

P921

Q47166330-1F75891C-1025-4BF8-81C4-7036CB9188CE

Q47166330-3FB5118E-4B71-4865-9800-F9894C1155D6

Q47166330-8D5C2905-7B15-4A72-A5DB-2E2C6D37B80C

P932

Q47166330-654AB357-0370-405E-8D8D-F64418886AF1

P356

P1433

Cell Death & Differentiation

P1476

The BCL-2 arbiters of apoptosis and their growing role as cancer targets.

@en

P275

Creative Commons Attribution 4.0 International

P2860

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer

Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics

Structure of Bax: coregulation of dimer formation and intracellular localization

P2888

P304

27-36

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/CDD.2017.161

http://www.w3.org/2001/XMLSchema#string

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

25

http://www.w3.org/2001/XMLSchema#string

P50

P577

2017-11-03T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

2018-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

29099483

http://www.w3.org/2001/XMLSchema#string

P921

proto-oncogene proteins

neoplasm proteins

P932

5729526

http://www.w3.org/2001/XMLSchema#string