Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation - Wikidata - wikimedia - TriplyDB

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

http://www.wikidata.org/entity/Q33707203

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Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease Nrf2 as a master regulator of tissue damage control and disease tolerance to infection Hydrogen peroxide - production, fate and role in redox signaling of tumor cells Antioxidant responses and cellular adjustments to oxidative stress Hydrogen peroxide sensing, signaling and regulation of transcription factors The redox biochemistry of protein sulfenylation and sulfinylation TrxR1 as a potent regulator of the Nrf2-Keap1 response system Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection Mitochondria and reactive oxygen species: physiology and pathophysiology The effects of chromium(VI) on the thioredoxin system: implications for redox regulation A new model for raf kinase inhibitory protein induced chemotherapeutic resistance Role of Oxidative Stress in Thyroid Hormone-Induced Cardiomyocyte Hypertrophy and Associated Cardiac Dysfunction: An Undisclosed Story Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.Cytoprotective effects of mild plasma-activated medium against oxidative stress in human skin fibroblasts Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.Protein redox modification as a cellular defense mechanism against tissue ischemic injury.Oxidative stress and inflammation modulate Rev-erbα signaling in the neonatal lung and affect circadian rhythmicity.An overview of mechanisms of redox signaling.Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression.Proteomic and mass spectroscopic quantitation of protein S-nitrosation differentiates NO-donors.Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.The thioredoxin system in neonatal lung disease The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.Role of H2O2 in the oxidative effects of zinc exposure in human airway epithelial cells.A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model.Thiol-based redox switches and gene regulation Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers.Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients Linking oxidative events to inflammatory and adaptive gene expression induced by exposure to an organic particulate matter component.Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair.Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury.Chemical and biological mechanisms of phytochemical activation of Nrf2 and importance in disease prevention Caveolin-1 regulates cancer cell metabolism via scavenging Nrf2 and suppressing MnSOD-driven glycolysis.Organic nitrate metabolism and action: toward a unifying hypothesis and the future-a dedication to Professor Leslie Z. Benet.Involvement of redox state in the aging of Drosophila melanogaster.Reporter protein complementation imaging assay to screen and study Nrf2 activators in cells and living animals.

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P2860

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

http://www.wikidata.org/entity/Q33707203

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

@ast

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

@en

type

label

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

@ast

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

@en

prefLabel

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

@ast

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

@en

P1433

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P2860

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P356

JBC.M109.051714

P1433

Journal of Biological Chemistry

P1476

Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation

@en

P2093

Denis Biard

http://www.w3.org/2001/XMLSchema#string

Michel B Toledano

http://www.w3.org/2001/XMLSchema#string

Raphaël Guerois

http://www.w3.org/2001/XMLSchema#string

Simon Fourquet

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Cysteine-based regulation of the CUL3 adaptor protein Keap1

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3

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8463-8471

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scholarly article

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10.1074/JBC.M109.051714

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11

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285

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2010-01-08T00:00:00Z

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20061377

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2832995

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