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Cysteine-based regulation of the CUL3 adaptor protein Keap1

Cysteine-based regulation of the CUL3 adaptor protein Keap1

http://www.wikidata.org/entity/Q24629359

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Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation Nrf2 and Notch Signaling in Lung Cancer: Near the Crossroad KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2 Real time dynamic imaging and current targeted therapies in the war on cancer: a new paradigm Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation The emerging role of QSOX1 in cancer Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles.12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment Effects of combined alcohol and anti-HIV drugs on cellular stress responses in primary hepatocytes and hepatic stellate and kupffer cells Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer.Formation and signaling actions of electrophilic lipids NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions.Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.Toll-Like Receptor Signaling Induces Nrf2 Pathway Activation through p62-Triggered Keap1 Degradation.Role of Nrf2, HO-1 and GSH in Neuroblastoma Cell Resistance to Bortezomib Ketogenic diets, mitochondria, and neurological diseases.KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease.Cullin 3 as a novel target in diverse pathologies Tim-3 inhibits macrophage control of Listeria monocytogenes by inhibiting Nrf2.Modifying radiation damage.The cytoprotective role of the Keap1-Nrf2 pathway.Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease.Nrf2 promotes survival following exposure to ionizing radiation.Structural basis of Keap1 interactions with Nrf2.KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity.Extracts of Fruits and Vegetables Activate the Antioxidant Response Element in IMR-32 Cells.The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases.Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants.Nrf2-a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke.Nrf2 in toxicology and pharmacology: the good, the bad and the ugly?Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1-Nrf2 cell defense pathway New strategies to inhibit KEAP1 and the Cul3-based E3 ubiquitin ligases.Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate.Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation.Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells.Cold exposure induced oxidative stress and apoptosis in the myocardium by inhibiting the Nrf2-Keap1 signaling pathway.

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P2860

Cysteine-based regulation of the CUL3 adaptor protein Keap1

http://www.wikidata.org/entity/Q24629359

description

2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Cysteine-based regulation of the CUL3 adaptor protein Keap1

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Cysteine-based regulation of the CUL3 adaptor protein Keap1

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Cysteine-based regulation of the CUL3 adaptor protein Keap1

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type

label

Cysteine-based regulation of the CUL3 adaptor protein Keap1

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Cysteine-based regulation of the CUL3 adaptor protein Keap1

@en

Cysteine-based regulation of the CUL3 adaptor protein Keap1

@nl

prefLabel

Cysteine-based regulation of the CUL3 adaptor protein Keap1

@ast

Cysteine-based regulation of the CUL3 adaptor protein Keap1

@en

Cysteine-based regulation of the CUL3 adaptor protein Keap1

@nl

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P356

J.TAAP.2009.06.016

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Toxicology and Applied Pharmacology

P1476

Cysteine-based regulation of the CUL3 adaptor protein Keap1

@en

P2093

Girish Rachakonda

http://www.w3.org/2001/XMLSchema#string

Konjeti R Sekhar

http://www.w3.org/2001/XMLSchema#string

Michael L Freeman

http://www.w3.org/2001/XMLSchema#string

P2860

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors.

BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity

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21-6

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scholarly article

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2803081

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10.1016/J.TAAP.2009.06.016

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1

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244

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2010-04-01T00:00:00Z

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223861059

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19560482

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2837771

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