Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease. - Wikidata - wikimedia - TriplyDB

Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.

Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.

http://www.wikidata.org/entity/Q33708589

about

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal Structure of a novel phosphotyrosine-binding domain in Hakai that targets E-cadherin Ubiquitylation as a Rheostat for TCR Signaling: From Targeted Approaches Toward Global Profiling Ubiquitin in the immune system RIP2 activity in inflammatory disease and implications for novel therapeutics Itch is required for lateral line development in zebrafish Mechanism-Based Strategies for the Management of Autoimmunity and Immune Dysregulation in Primary Immunodeficiencies Advantages of Extracellular Ubiquitin in Modulation of Immune Responses Genetics of inflammatory bowel disease from multifactorial to monogenic forms Genetic mapping and exome sequencing identify variants associated with five novel diseases Genetics and pathogenesis of inflammatory bowel disease E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) and IPEX-related disorders: an evolving web of heritable autoimmune diseases.A splice site variant in the bovine RNF11 gene compromises growth and regulation of the inflammatory response.A homozygous missense mutation in HERC2 associated with global developmental delay and autism spectrum disorder.When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease.Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications Itch E3 ubiquitin ligase positively regulates TGF-β signaling to EMT via Smad7 ubiquitination.Gene/cell therapy approaches for Immune Dysregulation Polyendocrinopathy Enteropathy X-linked syndrome.Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation.p63 threonine phosphorylation signals the interaction with the WW domain of the E3 ligase Itch A discrete ubiquitin-mediated network regulates the strength of NOD2 signaling.Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells Female mice with loss-of-function ITCH display an altered reproductive phenotype Ubiquitin e3 ligase itch negatively regulates osteoblast differentiation from mesenchymal progenitor cells The emerging role of the ubiquitin proteasome in pulmonary biology and disease.Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.Emerging therapies targeting the ubiquitin proteasome system in cancer De novo PHIP-predicted deleterious variants are associated with developmental delay, intellectual disability, obesity, and dysmorphic features New molecular targets for the treatment of sarcoidosis.Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells.Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins Ubiquitination and phosphorylation in the regulation of NOD2 signaling and NOD2-mediated disease Crosstalk between kinases and Nedd4 family ubiquitin ligases.Multifaceted role of the ubiquitin ligase Itch in immune regulation.The E3 ligase Itch in immune regulation and beyond.

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Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease.

http://www.wikidata.org/entity/Q33708589

description

2010 nî lūn-bûn

@nan

2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Human ITCH E3 ubiquitin ligase ...... ultisystem autoimmune disease.

@ast

Human ITCH E3 ubiquitin ligase ...... ultisystem autoimmune disease.

@en

type

label

Human ITCH E3 ubiquitin ligase ...... ultisystem autoimmune disease.

@ast

Human ITCH E3 ubiquitin ligase ...... ultisystem autoimmune disease.

@en

prefLabel

Human ITCH E3 ubiquitin ligase ...... ultisystem autoimmune disease.

@ast

Human ITCH E3 ubiquitin ligase ...... ultisystem autoimmune disease.

@en

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J.AJHG.2010.01.028

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American Journal of Human Genetics

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Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease

@en

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D Holmes Morton

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Erik G Puffenberger

http://www.w3.org/2001/XMLSchema#string

Kevin A Strauss

http://www.w3.org/2001/XMLSchema#string

Kudakwashe R Chikwava

http://www.w3.org/2001/XMLSchema#string

Naomi J Lohr

http://www.w3.org/2001/XMLSchema#string

Nicholas L Rider

http://www.w3.org/2001/XMLSchema#string

Oscar W Cummings

http://www.w3.org/2001/XMLSchema#string

Robert H Squires

http://www.w3.org/2001/XMLSchema#string

Wilfredo Torres-Martinez

http://www.w3.org/2001/XMLSchema#string

P2860

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways

Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function

The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.

GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells

Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor

Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?

Idiopathic nonspecific interstitial pneumonia: lung manifestation of undifferentiated connective tissue disease?

E3 ubiquitin ligases as T cell anergy factors.

Drug discovery in the ubiquitin-proteasome system.

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447-453

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scholarly article

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10.1016/J.AJHG.2010.01.028

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P433

3

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86

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Jean P. Molleston

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2010-02-18T00:00:00Z

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41507682

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20170897

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2833372

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