Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+)
about
Developmental neurotoxicity - challenges in the 21st century and in vitro opportunitiesMitochondrial dysfunction remodels one-carbon metabolism in human cellsReference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use.Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolismRapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia.Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration.The epigenetic regulation of HIF-1α by SIRT1 in MPP(+) treated SH-SY5Y cellsA LUHMES 3D dopaminergic neuronal model for neurotoxicity testing allowing long-term exposure and cellular resilience analysis.Cell fate determination, neuronal maintenance and disease state: The emerging role of transcription factors Lmx1a and Lmx1b.3D Differentiation of LUHMES Cell Line to Study Recovery and Delayed Neurotoxic Effects.Metabolic Alterations and the Protective Effect of Punicalagin Against Glutamate-Induced Oxidative Toxicity in HT22 Cells.In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.Characterization of three human cell line models for high-throughput neuronal cytotoxicity screening.Switching from astrocytic neuroprotection to neurodegeneration by cytokine stimulation.Systems Toxicology: The Future of Risk AssessmentA human brain microphysiological system derived from induced pluripotent stem cells to study neurological diseases and toxicity.MPTP's pathway of toxicity indicates central role of transcription factor SP1.The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency.Metabolic reprogramming during neuronal differentiation.Adverse outcome pathways: opportunities, limitations and open questionsDJ1 at the interface between neuro-degeneration and cancer.From smoking guns to footprints: mining for critical events of toxicity pathways in transcriptome data.The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress.mPOS is a novel mitochondrial trigger of cell death - implications for neurodegeneration.Mitochondrial retrograde signaling in the nervous system.Rotenone exerts developmental neurotoxicity in a human brain spheroid model.
P2860
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P2860
Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+)
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Transcriptional and metabolic ...... mitochondrial toxicant MPP(+)
@ast
Transcriptional and metabolic ...... mitochondrial toxicant MPP(+)
@en
type
label
Transcriptional and metabolic ...... mitochondrial toxicant MPP(+)
@ast
Transcriptional and metabolic ...... mitochondrial toxicant MPP(+)
@en
prefLabel
Transcriptional and metabolic ...... mitochondrial toxicant MPP(+)
@ast
Transcriptional and metabolic ...... mitochondrial toxicant MPP(+)
@en
P2093
P2860
P50
P356
P1476
Transcriptional and metabolic ...... mitochondrial toxicant MPP(+)
@en
P2093
A Sachinidis
C Kullmann
P2860
P2888
P356
10.1038/CDDIS.2014.166
P577
2014-05-08T00:00:00Z
P5875
P6179
1000313770