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Toxicity testing in the 21st century: a vision and a strategy

Toxicity testing in the 21st century: a vision and a strategy

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Estimating the effective density of engineered nanomaterials for in vitro dosimetry Value of monitoring Nrf2 activity for the detection of chemical and oxidative stress Novel in vitro and mathematical models for the prediction of chemical toxicity State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing Hydra as a model organism to decipher the toxic effects of copper oxide nanorod: Eco-toxicogenomics approach.Computational methods for prediction of in vitro effects of new chemical structures Use of In Vivo and In Vitro Data to Derive a Chronic Reference Value for Crotonaldehyde Based on Relative Potency to Acrolein Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water Pesticide exposure and neurodevelopmental outcomes: review of the epidemiologic and animal studies.An integrated approach for the in vitro dosimetry of engineered nanomaterials Developmental neurotoxicity - challenges in the 21st century and in vitro opportunities Implications of in vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials Morphological and chemical mechanisms of elongated mineral particle toxicities Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos Advanced computational modeling for in vitro nanomaterial dosimetry Interactions of engineered nanomaterials in physiological media and implications for in vitro dosimetry Toxicity testing in the 21 century: defining new risk assessment approaches based on perturbation of intracellular toxicity pathways Developing tools for defining and establishing pathways of toxicity A computational approach to evaluate the androgenic affinity of iprodione, procymidone, vinclozolin and their metabolites Hydrogel Based 3-Dimensional (3D) System for Toxicity and High-Throughput (HTP) Analysis for Cultured Murine Ovarian Follicles t4 workshop report: Pathways of Toxicity High-throughput imaging-based nephrotoxicity prediction for xenobiotics with diverse chemical structures Editor's Highlight: Development of an In vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment On Crowd-verification of Biological Networks Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing Reduced biological effect of e-cigarette aerosol compared to cigarette smoke evaluated in vitro using normalized nicotine dose and RNA-seq-based toxicogenomics.Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.Scientific and Regulatory Policy Committee: Recommended ("Best") Practices for Determining, Communicating, and Using Adverse Effect Data from Nonclinical Studies.A comparison of machine learning algorithms for chemical toxicity classification using a simulated multi-scale data model.Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+)Self-organizing map analysis of toxicity-related cell signaling pathways for metal and metal oxide nanoparticles CSEO - the Cigarette Smoke Exposure Ontology.Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening.Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.Toxicologic pathology in the 21st century.Evaluation of the INS-1 832/13 cell line as a beta-cell based screening system to assess pollutant effects on beta-cell function.A C. elegans screening platform for the rapid assessment of chemical disruption of germline function.

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Toxicity testing in the 21st century: a vision and a strategy

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2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010年の論文

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Journal of Toxicology and Environmental Health Part B: Critical Reviews

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Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring.

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Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant

Nanoparticles: health effects - pros and cons

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Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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