Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots.
about
Panhandle and reverse-panhandle PCR enable cloning of der(11) and der(other) genomic breakpoint junctions of MLL translocations and identify complex translocation of MLL, AF-4, and CDK6.Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia.Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemiaDietary flavonoids and the MLL gene: A pathway to infant leukemia?Immunologically silent cancer clone transmission from mother to offspringDietary bioflavonoids induce cleavage in the MLL gene and may contribute to infant leukemiaRevisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemiaLeukemogenic rearrangements at the mixed lineage leukemia gene (MLL)-multiple rather than a single mechanismThe quiescent cellular state is Arf/p53-dependent and associated with H2AX downregulation and genome stabilityRAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures.Childhood acute lymphoblastic leukemia: Integrating genomics into therapyGerminal and Somatic Trisomy 21 Mosaicism: How Common is it, What are the Implications for Individual Carriers and How Does it Come About?Biomarkers of leukemia risk: benzene as a modelPerspectives on the causes of childhood leukemiaResidential pesticides and childhood leukemia: a systematic review and meta-analysisRisk factors for acute leukemia in children: a reviewMaternal exposure to household chemicals and risk of infant leukemia: a report from the Children's Oncology GroupArchived unfrozen neonatal blood spots are amenable to quantitative gene expression analysis.Prenatal origin of childhood AML occurs less frequently than in childhood ALL.Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesisDiscordance of MLL-rearranged (MLL-R) infant acute lymphoblastic leukemia in monozygotic twins with spontaneous clearance of preleukemic clone in unaffected twin.FLT3 mutation incidence and timing of origin in a population case series of pediatric leukemia.Mll rearrangements in haematological malignancies: lessons from clinical and biological studies.Childhood leukaemia.Genetic variation in the folate metabolic pathway and risk of childhood leukemia.Infant leukemia and parental infertility or its treatment: a Children's Oncology Group report.Exposure to infections and risk of leukemia in young children.Maternal and offspring genetic variants of AKR1C3 and the risk of childhood leukemia.Chromosome translocations and covert leukemic clones are generated during normal fetal developmentMLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomGenetic predisposition and treatment-related leukemia.Chapter 11: challenges in and principles for conducting systematic reviews of genetic tests used as predictive indicators.Maternal vitamin and iron supplementation and risk of infant leukaemia: a report from the Children's Oncology Group.The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemiasMLL leukemia-associated rearrangements in peripheral blood lymphocytes from healthy individuals.Chromosomal rearrangements leading to MLL gene fusions: clinical and biological aspectsCured meat, vegetables, and bean-curd foods in relation to childhood acute leukemia risk: a population based case-control study.Analgesic use during pregnancy and risk of infant leukaemia: a Children's Oncology Group studyGenetic profile of acute myeloid leukemia.Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants.
P2860
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P2860
Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots.
description
1997 nî lūn-bûn
@nan
1997 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
name
Backtracking leukemia to birth ...... ences in neonatal blood spots.
@ast
Backtracking leukemia to birth ...... ences in neonatal blood spots.
@en
type
label
Backtracking leukemia to birth ...... ences in neonatal blood spots.
@ast
Backtracking leukemia to birth ...... ences in neonatal blood spots.
@en
prefLabel
Backtracking leukemia to birth ...... ences in neonatal blood spots.
@ast
Backtracking leukemia to birth ...... ences in neonatal blood spots.
@en
P2093
P2860
P356
P1476
Backtracking leukemia to birth ...... ences in neonatal blood spots.
@en
P2093
A Borkhardt
M F Greaves
P2860
P304
13950-13954
P356
10.1073/PNAS.94.25.13950
P407
P577
1997-12-01T00:00:00Z