Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition.
about
Structural basis of interleukin-5 dimer recognition by its α receptorRandomization of the receptor alpha chain recruitment epitope reveals a functional interleukin-5 with charge depletion in the CD loop.Receptor epitope usage by an interleukin-5 mimetic peptide.Coiled coil miniprotein randomization on phage leads to charge pattern mimicry of the receptor recognition determinant of interleukin 5.Asymmetric usage of antagonist charged residues drives interleukin-5 receptor recruitment but is insufficient for receptor activationExamination of the kinetics of herpes simplex virus glycoprotein D binding to the herpesvirus entry mediator, using surface plasmon resonanceUtilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range.The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for functionExpression and in vitro properties of guinea pig IL-5: comparison to human and murine orthologs.Neutralizing monoclonal antibodies can potentiate IL-5 signaling.Molecular interaction analysis in ligand design using mass transport, kinetic and thermodynamic methods.Single chain human interleukin 5 and its asymmetric mutagenesis for mapping receptor binding sites.Biological and molecular characteristics of interleukin-5 and its receptor.Mutants of single chain interleukin 5 show asymmetric recruitment of receptor alpha and betac subunits.Kinetic interaction analysis of human interleukin 5 receptor alpha mutants reveals a unique binding topology and charge distribution for cytokine recognition.Epitope randomization redefines the functional role of glutamic acid 110 in interleukin-5 receptor activation.Spatial Orientation of the α and βcReceptor Chain Binding Sites on Monomeric Human Interleukin-5 Constructs
P2860
Q27678698-B14E9E5E-7B04-44C6-B1D6-9D47B505D8ECQ30731308-63F5A9D8-A3B9-4CBB-96C1-632F0EE7E62EQ31159556-72E073AC-8909-4815-A2A5-B1917A548E0BQ32064627-1ADF3D38-0CFD-4749-969A-DFFB41CEC47CQ33232304-E8728D3D-A6BA-4839-93BB-D28BEA45F203Q33785686-23EF39EC-A59B-43D9-9A26-4461CDE3210FQ34218332-2E790497-7A6A-4556-9608-E1421161B1B3Q34304678-EB996034-889B-46CE-BFDC-70C1BA779693Q36239088-ECF5D1B0-46E7-42B8-9F4A-75D30B749FD3Q38305452-D7BE9F8F-5870-47E2-8B53-50009FD0EC4CQ40813340-FD53284B-0946-44AE-9800-D22C113DB26AQ41172876-5B3B2F9C-3A72-4F0E-B5AE-6EBBD238805AQ41237296-8B392F69-CB20-4701-82C4-DE7A1E0E13CBQ41722186-4DA15350-D0BF-4232-9505-92B5EBAC907FQ42645171-F2F5938B-57F3-4F9D-B62A-91F30815D7E6Q51598582-4EAD5CE0-78BB-4815-86E5-B3BD1DE82253Q54047807-F5115097-24E2-46E6-9AF6-3B1E0FD8C2DBQ57019220-EF16E935-A5C9-4F24-A7C1-DAA45547EDA2
P2860
Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition.
description
1995 nî lūn-bûn
@nan
1995 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Mutagenesis in the C-terminal ...... eptor alpha chain recognition.
@ast
Mutagenesis in the C-terminal ...... eptor alpha chain recognition.
@en
type
label
Mutagenesis in the C-terminal ...... eptor alpha chain recognition.
@ast
Mutagenesis in the C-terminal ...... eptor alpha chain recognition.
@en
prefLabel
Mutagenesis in the C-terminal ...... eptor alpha chain recognition.
@ast
Mutagenesis in the C-terminal ...... eptor alpha chain recognition.
@en
P2093
P2860
P356
P1476
Mutagenesis in the C-terminal ...... eptor alpha chain recognition.
@en
P2093
P2860
P304
10879-10883
P356
10.1073/PNAS.92.24.10879
P407
P577
1995-11-01T00:00:00Z