Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway - Wikidata - wikimedia - TriplyDB

Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway

Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway

http://www.wikidata.org/entity/Q33744417

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Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation Disruption of IkappaB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors.Tcl1 interacts with Atm and enhances NF-κB activation in hematologic malignancies.Predicting Response to Histone Deacetylase Inhibitors Using High-Throughput Genomics.YY1 is indispensable for Lgr5+ intestinal stem cell renewal.Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.Proteomic analysis identifies differentially expressed proteins after HDAC vorinostat and EGFR inhibitor gefitinib treatments in Hep-2 cancer cells.Histone deacetylase inhibitor (HDACI) mechanisms of action: emerging insights.Inhibiting NF-κB activation by small molecules as a therapeutic strategy.Novel approaches in anaplastic thyroid cancer therapy The combination of bendamustine, bortezomib, and rituximab for patients with relapsed/refractory indolent and mantle cell non-Hodgkin lymphoma Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo Nuclear initiated NF-κB signaling: NEMO and ATM take center stage.High throughput short interfering RNA (siRNA) screening of the human kinome identifies novel kinases controlling the canonical nuclear factor-κB (NF-κB) activation pathway.Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK1/2.LBH-589 (panobinostat) potentiates fludarabine anti-leukemic activity through a JNK- and XIAP-dependent mechanism.IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.Bortezomib interacts synergistically with belinostat in human acute myeloid leukaemia and acute lymphoblastic leukaemia cells in association with perturbations in NF-κB and Bim Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR.Targeting Waldenstrom macroglobulinemia with histone deacetylase inhibitors.Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect.DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out.Oxidative Stress Gene Expression Profile Correlates with Cancer Patient Poor Prognosis: Identification of Crucial Pathways Might Select Novel Therapeutic Approaches.A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax(®)).CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells.ATM is required for SOD2 expression and homeostasis within the mammary gland.Deacetylase inhibitors - focus on non-histone targets and effects.Simultaneous NF-κB inhibition and E-cadherin upregulation mediate mutually synergistic anticancer activity of celastrol and SAHA in vitro and in vivo.Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3).Targeting transcription factor lysine acetylation in inflammatory airway diseases

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Histone deacetylase inhibitors activate NF-kappaB in human leukemia cells through an ATM/NEMO-related pathway

http://www.wikidata.org/entity/Q33744417

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Histone deacetylase inhibitors ...... gh an ATM/NEMO-related pathway

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Histone deacetylase inhibitors ...... gh an ATM/NEMO-related pathway

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Histone deacetylase inhibitors ...... gh an ATM/NEMO-related pathway

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Histone deacetylase inhibitors ...... gh an ATM/NEMO-related pathway

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Histone deacetylase inhibitors ...... gh an ATM/NEMO-related pathway

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Histone deacetylase inhibitors ...... gh an ATM/NEMO-related pathway

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JBC.M109.095208

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Journal of Biological Chemistry

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Histone deacetylase inhibitors ...... gh an ATM/NEMO-related pathway

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Ankita Patel

http://www.w3.org/2001/XMLSchema#string

Jorge A Almenara

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Paul B Fisher

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Peter Atadja

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Roberto R Rosato

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Sanjay Amin

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Sarah S Kolla

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Stefanie K Hock

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Steven Grant

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P2860

Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

Identification of nucleophosmin as an NF-kappaB co-activator for the induction of the human SOD2 gene

Histone deacetylases (HDACs): characterization of the classical HDAC family

The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination

Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

Duration of nuclear NF-kappaB action regulated by reversible acetylation

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

Regulation of NF-kappaB action by reversible acetylation

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10064-10077

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scholarly article

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10.1074/JBC.M109.095208

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13

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285

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2010-01-11T00:00:00Z

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20065354

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2843169

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