Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
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Metabolomics applied to the pancreatic isletSignaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cellsChronic effects of palmitate overload on nutrient-induced insulin secretion and autocrine signalling in pancreatic MIN6 beta cellsHigh glucose exposure promotes activation of protein phosphatase 2A in rodent islets and INS-1 832/13 β-cells by increasing the posttranslational carboxylmethylation of its catalytic subunitPancreatic β-cell Raf-1 is required for glucose tolerance, insulin secretion, and insulin 2 transcriptionERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity.High glucose predisposes gene expression and ERK phosphorylation to apoptosis and impaired glucose-stimulated insulin secretion via the cytoskeletonPhagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.A farnesylated G-protein suppresses Akt phosphorylation in INS 832/13 cells and normal rat islets: regulation by pertussis toxin and PGE₂.EHT 1864, a small molecule inhibitor of Ras-related C3 botulinum toxin substrate 1 (Rac1), attenuates glucose-stimulated insulin secretion in pancreatic β-cells.Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.Metabolomics Analysis Reveals that AICAR Affects Glycerolipid, Ceramide and Nucleotide Synthesis Pathways in INS-1 Cells.Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.Protein farnesylation is requisite for mitochondrial fuel-induced insulin release: further evidence to link reactive oxygen species generation to insulin secretion in pancreatic β-cells.VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.Metabolome response to glucose in the β-cell line INS-1 832/13.Phagocytic NADPH oxidase links ARNO-Arf6 signaling pathway in glucose-stimulated insulin secretion from the pancreatic β-cell.Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells.Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells.Nifedipine prevents etoposide-induced caspase-3 activation, prenyl transferase degradation and loss in cell viability in pancreatic β-cells.The role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice.Role of G-proteins in islet function in health and diabetes.Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB.The role of Raf-1 kinase in diabetic retinopathy.
P2860
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P2860
Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Protein farnesylation-dependen ...... tion in pancreatic beta-cells.
@ast
Protein farnesylation-dependen ...... tion in pancreatic beta-cells.
@en
type
label
Protein farnesylation-dependen ...... tion in pancreatic beta-cells.
@ast
Protein farnesylation-dependen ...... tion in pancreatic beta-cells.
@en
prefLabel
Protein farnesylation-dependen ...... tion in pancreatic beta-cells.
@ast
Protein farnesylation-dependen ...... tion in pancreatic beta-cells.
@en
P2093
P2860
P356
P1433
P1476
Protein farnesylation-dependen ...... etion in pancreatic beta-cells
@en
P2093
Brandon J Koch
Christopher J Rhodes
Rajakrishnan Veluthakal
Vasudeva Kamath
P2860
P304
P356
10.2337/DB09-1334
P407
P577
2010-01-13T00:00:00Z